Biosensor device and method

Details Biosensor device and method Biosensor device and method

1997-04-24

2000-08-22

Chin, Christopher L.

Chemistry: molecular biology and microbiology

Apparatus

204400, 204403, 204416, 204418, 204290R, 422 8201, 422 8203, 435 6, 4352871, 4352872, 435817, 436149, 436150, 436518, 436528, 436806, G01N 33544

Patent

active

061070807

ABSTRACT:
A biosensor apparatus for detecting a binding event between a ligand and receptor. The apparatus includes an electrode substrate coated with a high-dielectric hydrocarbon-chain monolayer, and having ligands attached to the exposed monolayer surface. Binding of a receptor to the monolayer-bound ligand, and the resultant perturbation of the monolayer structure, causes ion-mediated electron flow across the monolayer. In one embodiment, the monolayers have a coil-coil heterodimer embedded therein, one subunit of which is attached to the substrate, and the second of which carries the ligand at the monolayer surface.

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