Biosensor device and method

Details Biosensor device and method Biosensor device and method

1997-04-24

1999-09-21

Housel, James C.

Chemistry: analytical and immunological testing

Involving an insoluble carrier for immobilizing immunochemicals

Carrier is organic

436518, 436525, 436528, 436807, 436806, 436904, 435 71, 435 75, 427 211, 422 8202, G01N 33533

Patent

active

059553790

ABSTRACT:
A biosensor apparatus for detecting a binding event between a ligand and receptor. The apparatus includes an electrode substrate coated with a high-dielectric hydrocarbon-chain monolayer, and having ligands attached to the exposed monolayer surface. Binding of a receptor to the monolayer-bound ligand, and the resultant perturbation of the monolayer structure, causes ion-mediated electron flow across the monolayer. In one embodiment, the monolayers have a coil--coil heterodimer embedded therein, one subunit of which is attached to the substrate, and the second of which carries the ligand at the monolayer surface.

REFERENCES:
patent: 4789804 (1988-12-01), Karube et al.
patent: 5089112 (1992-02-01), Skotkeim et al.
patent: 5204239 (1993-04-01), Gitler et al.
patent: 5242828 (1993-09-01), Bergstrom et al.
patent: 5268305 (1993-12-01), Ribi et al.
patent: 5313264 (1994-05-01), Ivarsson et al.
patent: 5368712 (1994-11-01), Tomich et al.
patent: 5401378 (1995-03-01), King et al.
patent: 5436161 (1995-07-01), Bergstrom et al.
patent: 5436170 (1995-07-01), Cornell et al.
patent: 5478756 (1995-12-01), Gizeli et al.
patent: 5485277 (1996-01-01), Foster
patent: 5491097 (1996-02-01), Ribi et al.
patent: 5492840 (1996-02-01), Malmqvist et al.
patent: 5514501 (1996-05-01), Tarlov
patent: 5567301 (1996-10-01), Stetter et al.
patent: 5571568 (1996-11-01), Ribi et al.
CRC Handbook of Chemistry and Physics, 67th edition, CRC Press, Inc., Boca Raton, Florida, pp. D151, D153, D155-D158, 123, 127, 1986.
Dakkouri, A.S et al., "Scanning Tunneling Microscopy Study of L-Cysteine on Au(111)," Langmuri, 12,:2849-2852, 1996.
Khilko, S, et al., "Measuring interaction of MHC class I molecules using surface plasmon resonance", J. Immunological Methods, 183 (1995).

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