Biosensing meter with fail/safe procedures to prevent erroneous

Chemistry: electrical and wave energy – Apparatus – Electrolytic

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204407, 204403, G01N 2726

Patent

active

053523512

ABSTRACT:
A biosensing meter receives a sample strip that includes electrically isolated sense and excitation electrodes bridged by a reaction zone. When a drop of biological sample fluid is placed in the reaction zone, a plurality of fail/safe tests are performed. A drop size test is performed by a circuit that detects the size of the drop placed in the reaction zone. The circuit both detects that a drop has been placed in the reaction zone and further measures a test current level, after a delay, to determine that the drop size is sufficient to enable hydration of reactants in the reaction zone. Subsequently, during the reaction, a "delta" current change is measured at succeeding sample time. This test measures the difference between succeeding current samples during a measurement time. If each succeeding sample is not less than preceding sample by a delta value, a determination is made that the current is not monotonically decreasing and the test is aborted. At the termination of the measurement time, a current sum test is performed wherein a processor calculates a linear sum of all sample test currents and calculates a ratio between that sum and the last current sample. If that ratio matches a pre-calculated constant for the Cottrell relationship, then it is known that the measurement values exhibit the Cottrell relationship.

REFERENCES:
patent: 4420564 (1983-12-01), Tsuji et al.
patent: 4940945 (1990-07-01), Littlejohn et al.
patent: 4999582 (1991-03-01), Parks et al.
patent: 5053199 (1991-10-01), Keiser et al.
patent: 5108564 (1992-04-01), Szuminsky et al.

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