Drug – bio-affecting and body treating compositions – Extract – body fluid – or cellular material of undetermined... – Derived from musculoskeletal system – other than cardiac muscle
Reexamination Certificate
2007-11-09
2011-10-18
Ariani, Kade (Department: 1651)
Drug, bio-affecting and body treating compositions
Extract, body fluid, or cellular material of undetermined...
Derived from musculoskeletal system, other than cardiac muscle
C514S772300, C604S265000, C606S060000, C623S001150, C623S001420, C623S018110
Reexamination Certificate
active
08039021
ABSTRACT:
A bioerodible composition for delivery of a bioactive agent is the reaction product of a reaction mixture which includes an oxidized dextran solution, and a mixture of solids containing a dihydrazide, a bioactive agent, and optionally a pH adjusting agent in an amount sufficient to achieve a pH of the reaction mixture of 6 or less. The composition may include a release agent for controlled release of the bioactive agent from the composition. A bioactive agent may therefore be administered to a body site in need of the same by providing a first aliquot portion of a reaction mixture comprising an oxidized dextran solution, and a second aliquot portion of a reaction mixture comprising a mixture of solids comprised of a dihydrazide, a bioactive agent, and a solid acid which is present in an amount sufficient to achieve a pH of the reaction mixture of 6 or less, mixing the first and second aliquot portions to form the reaction mixture thereof, and thereafter installing the reaction mixture at the body site and allowing a solidified bioerodible drug delivery composition to be formed thereby in situ.
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Ariani Kade
Nixon & Vanderhye P.C.
Royer Biomedical, Inc.
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