Bioreductive cytotoxic agents

Organic compounds -- part of the class 532-570 series – Organic compounds – Four or more ring nitrogens in the bicyclo ring system

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5142378, 514393, 514412, 514471, 514533, 514535, 5483027, 548516, 549496, 560 24, 560 46, 560 47, C07D26530, C07D23502, C07Z26100, C07Z22960

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active

059691336

ABSTRACT:
A compound which consists of a proactive alkylating moiety containing an electron-withdrawing group, a bioreductive moiety containing at least two double bonds, and a linker joining the proactive alkylating moiety and the bioreductive moiety.

REFERENCES:
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patent: 5602278 (1997-02-01), Kirkpatrick
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Database CAPLUS on STN, Acc. No. 1983:594554, Witiak et al., `Bis(bioreductive) alkylating agents: synthesis and biological activity in a nude mouse human carcinoma model.` J. Med. Chem. (1983), 26(12), 1679-86. (abstract).

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