Chemistry: molecular biology and microbiology – Apparatus – Bioreactor
Patent
1986-09-22
1990-01-16
Richman, Barry S.
Chemistry: molecular biology and microbiology
Apparatus
Bioreactor
435240242, 435284, 435285, 435313, 435813, 435818, C12M 104, C12M 114, C12M 134
Patent
active
048943428
ABSTRACT:
An improved bioreactor system for culturing cell products is disclosed in which novel system components are employed to reduce cost and increase reliability. The system includes a simple in-line heater for heating the nutrient fluid, thereby obviating the need for an expensive incubator. Gas bubbles formed during the heating of the nutrient fluid are removed by a novel gas trap that requires no operator intervention. A humidifier humidifies an aerating gas before it is passed through an oxygenator, thereby preventing water within the nutrient fluid from evaporating, with a consequent increase in nutrient fluid concentration. The operation of the humidifier is efficiently combined with that of a nutrient fluid heat exchanger so that a pump is not required to circulate the heat exchanger water bath. The system further includes a valve and pump arrangement whereby fresh nutrient fluid can periodically be introduced and spent nutrient fluid periodically drained without operator intervention. Observation of the color of the nutrient fluid from a concealed location within the bioreactor enclosure is also made possible.
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Guinn Perry W.
Mills Gary N.
C. D. Medical, Inc.
McMahon Timothy M.
Richman Barry S.
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