Bioreactor mediated recellularization of natural and tissue...

Prosthesis (i.e. – artificial body members) – parts thereof – or ai – Arterial prosthesis – Having living cell

Reexamination Certificate

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C435S174000, C435S325000, C435S395000, C424S422000, C623S001100

Reexamination Certificate

active

10260007

ABSTRACT:
Processes for producing a tissue graft comprising acellularizing or devitalizing a tubular tissue to produce a tissue matrix. The tissue matrix is then populated with at least some viable cells. The processing and the populating steps are performed in a closed system, such as a bioreactor. Tissue grafts produced using the inventive processes may be capable of withstanding physiological stress and strain conditions present at a site into which the tissue graft is implanted.

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