Bioreactor apparatus with surface aerator screen

Chemistry: molecular biology and microbiology – Miscellaneous

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Details

435312, 261 91, 261120, 366316, C12M 102

Patent

active

047600284

ABSTRACT:
A bioreactor for cell culture medium is provided including a flask for holding the culture medium, a screen at or just below the surface of the culture medium, a mover for the screen to cause it to move generally parallel to the surface of the culture medium, and an integral or separate impeller to cause circulation of the culture medium to the surface of the liquid culture medium. The screen is preferably on a float, and is connected to be driven at different levels of the liquid in the flask.

REFERENCES:
patent: 2556854 (1951-06-01), Spears et al.
patent: 3273865 (1966-09-01), White
patent: 4512666 (1985-04-01), O'Connell
patent: 4581181 (1986-04-01), Nicholls
patent: 4603021 (1986-07-01), Urso
Handa et al., "On the Evaluation of Gas-Liquid Interfacial Effects on Hybridoma Viability in Bubble Column Reactors", from Develop. Biol. Standard, vol. 66, Abstract of pp. 241-253.
"Mammalian Cell Technology", edited by William G. Tilly, published by Buttersworth, Jul. 1986.

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