Chemistry: molecular biology and microbiology – Apparatus – Bioreactor
Patent
1986-05-12
1989-12-26
Richman, Barry S.
Chemistry: molecular biology and microbiology
Apparatus
Bioreactor
435285311, 435313, 435813, C12M 104, C12M 114, C12M 134
Patent
active
048898120
ABSTRACT:
A novel class of bioreactor apparatuses are disclosed which offer improved performance over prior art designs. The apparatuses circulate nutrient fluid through a bioreactor device, such as a hollow fiber bioreactor cartridge, which is used to culture a colony of cells. The nutrient fluid is refreshed by the controlled addition of fresh fluid and the controlled removal of used fluid through a sterile infusion/extraction device. Cellular by-product yield is enhanced by periodically alternating the direction of nutrient fluid through the bioreactor and by periodically circulating the harvest fluid through the extracapillary region of the bioreactor cartridge.
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Bedient Robert A.
Greeley Martin O.
Guinn Perry W.
Mills Gary N.
C. D. Medical, Inc.
McMahon Timothy M.
Richman Barry S.
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