Chemistry: molecular biology and microbiology – Apparatus – Differentiated tissue perfusion or preservation apparatus
Patent
1993-06-11
1994-12-27
Beisner, William H.
Chemistry: molecular biology and microbiology
Apparatus
Differentiated tissue perfusion or preservation apparatus
435285, 435311, C12M 300, C12M 306, C12M 304
Patent
active
053765486
ABSTRACT:
A bioreactor apparatus for producing metabolites from bioorganisms by depositing the animal cells on a carrier made of a porous material. The apparatus includes a hermetically sealed container (1) having a first supply channel A, for supplying a liquid containing animal cells into the inside thereof, a second supply channel (B) for supplying a culture solution and a substrate solution into the inside thereof, a first exhaust channel (a) for exhausting a liquid containing suspended animal cells from the inside thereof, and a second exhaust channel (b) for exhausting a residual part of the culture solution, a residual part of the substrate solution and a solution containing metabolites of the animal cells from the inside thereof. Disposed within the container is an animal culture base including a porous carrier (31, 33, 34) and a culture bed (4) arranged so that liquid supplied from the supply channels (A, B) are brought into contact therewith while flowing in the inside of the container (1). Further, the apparatus includes a filtration membrane (6) arranged across the second exhaust channel (b) in the inside of the container (1) and provided for filtrating a liquid to be exhausted through the second exhaust channel (b).
REFERENCES:
patent: 3853712 (1974-12-01), House et al.
patent: 4546083 (1985-10-01), Meyers et al.
patent: 4833083 (1989-05-01), Saxena
patent: 4861725 (1989-08-01), Liau
patent: 5057428 (1991-10-01), Mizutani et al.
Matsuo Shigeru
Nishimura Masato
Beisner William H.
Fuji Photo Film Co. , Ltd.
Kirin Brewery Co. Ltd.
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