Prosthesis (i.e. – artificial body members) – parts thereof – or ai – Heart valve – Having rigid or semirigid pivoting occluder
Patent
1995-06-07
1997-12-16
Prebilic, Paul B.
Prosthesis (i.e., artificial body members), parts thereof, or ai
Heart valve
Having rigid or semirigid pivoting occluder
623 11, 623901, 8 9411, 427 225, A61F 224
Patent
active
056979720
ABSTRACT:
The specification describes an invention of calcification resistant bioprosthetic heart valves which can be used for a long term, and have good blood compatibility and in vivo stability, and have high calcification resistance. The bioprosthetic heart valves of the invention can be prepared by binding sulfonated polyethylene oxide (PEO) derivatives covalently to the tissue. The valves have an anionic effect equal to that of chondroitin sulfate, space filling effect, and blocking effect of the carboxyl group of collagen which has been known as one factor of the calcium deposition,. In particular, the present method has better advantages in view of calcification resistance than any other conventional methods, because it suppresses thrombosis and embolism and decreases incidence of infection.
REFERENCES:
patent: 4838888 (1989-06-01), Nasher
patent: 4976733 (1990-12-01), Girardot
patent: 5116361 (1992-05-01), Kim et al.
patent: 5182317 (1993-01-01), Winters et al.
patent: 5216087 (1993-06-01), Kim et al.
patent: 5476516 (1995-12-01), Seifter et al.
patent: 5507804 (1996-04-01), Llanos
In vivo "Calcification of Sulfonated PEO-grafted Biological Tissues," K.D. Park, J.Y. Yun, D.K. Han, S.Y. Jeong, K.T. Kim, H.M. Kim and Y.H. Kim, The 21st Annual Meeting of the Society for Biomaterials, Mar. 18-22, 1995, San Francisco, California, USA.
J. Biomed. Mater. Res.: Applied Biomaterials, vol. 22, pp. 11-36, 1988, F. J. Schoen, et al., "Biomaterial-Associated Calcification: Pathology, Mechanisms, and Strategies For Prevention".
Journal of Biomedical Materials Research, vol. 25, pp. 85-98, 1991, G. Golomb, et al., "Prevention of Bioprosthetic Heart Valve Tissue Calcification By Charge Modification: Effects of Protamine Binding By Formaldehyde".
The 17th Annual Meeting of the Society For Biomaterials, p. 61, May 1-5, 1991, Matthew Baldwin, et al., "FE3' Pretreatment Provides Sustained Inhibition of Bioprosthetic Heart Valve calcification".
Han Dong Keun
Kim Hack Joo
Kim Young Ha
Park Ki Dong
Korea Institute of Science and Technology
Prebilic Paul B.
LandOfFree
Bioprosthetic heart valves having high calcification resistance does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Bioprosthetic heart valves having high calcification resistance, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Bioprosthetic heart valves having high calcification resistance will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-201781