Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing compound having a 1-thia-5-aza-bicyclo
Patent
1994-05-27
1996-09-24
Low, Christopher S. F.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing compound having a 1-thia-5-aza-bicyclo
435 49, 435 51, 435183, 435230, 435243, 43525411, 4353201, 4351723, 4352545, 536 231, 536 232, 536 2374, C12P 354, C12P 3500, C12N 116
Patent
active
055590055
ABSTRACT:
Important intermediates for preparing cephalosporin antibiotics, 7-amino-cephalosporanic acid (7-ACA) and 7-aminodeacetylcephalosporanic acid (7-ADAC), are prepared by a novel bioprocess in which a transformed Penicillium chrysogenum strain is cultured in the presence of an adipate feedstock to produce adipoyl-6-APA (6-amino penicillanic acid); followed by the in situ expression of the following genes with which the P. chrysogenum has been transformed:
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Conder Michael J.
McAda Phyllis C.
Rambosek John A.
Reeves Christopher D.
Low Christopher S. F.
Merck & Co. , Inc.
Meredith Roy D.
Tribble Jack L.
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