Biopolymeric membranes

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Web – sheet or filament bases; compositions of bandages; or...

Reexamination Certificate

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C424S445000, C424S447000, C424S449000, C424S402000

Reexamination Certificate

active

07807192

ABSTRACT:
This invention relates to a sheet membrane for repairing a damaged tissue. The membrane includes an isotropic layer of cross-linked biopolymeric fibers in which the fibers are 10 to 1,000 cm in length. This invention also relates to a method of making an isotropic layer of cross-linked biopolymeric fibers. The method includes: (1) coacervating biopolymeric fibers (e.g., collagen-based fibers) having lengths of less than 1 cm dispersed in an aqueous solution to obtain coacervated biopolymeric fibers having lengths of 10 to 1,000 cm; (2) flattening the coacervated biopolymeric fibers into a layer; (3) drying the layer; and (4) cross-linking the biopolymeric.

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Oneson et al., “The Preparation of Highly Purified Insoluble Collagens”, Journal of the American Leather Chemists Association 65:440-450, 1970.
Yuen et al., “A Resorbable, Reconstituted Type I Collagen Membrane for Guided Tissue Regeneration and Soft Tissue Augmentation”, Transactions of the Sixth World Biomaterials Congress p. 1288, 2000.

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