Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Matrices
Patent
1994-01-14
1995-10-31
Webman, Edward J.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Matrices
424486, 424501, 935 88, 422 8202, 422 64, A61K 910, A61K 916, C07K 106, C07K 110, B65D 326, B01J 1918
Patent
active
054627486
ABSTRACT:
A cartridge containing a dry polymer composition carrying trapped biopolymer subunits for use in synthesis of biopolymer chains provides a discrete unit for stepwise supply of subunits, such as protected amino acids, in an automated apparatus for biopolymer synthesis. The composition is swellable in organic solvent to release and supply the subunits to a growing biopolymer chain immobilized on a polymer support. An automated synthesizer uses the cartridges for sequential subunit supply and monitors conductivity of deprotection reagents to control cycling and timing of steps.
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DeFranco Robert J.
Ladd Charles S.
Lloyd David H.
Applied Biosystems Inc.
Dehlinger Peter J.
Powers Vincent M.
Webman Edward J.
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