Biopolymer-bound nitric oxide-releasing compositions, pharmaceut

Details Biopolymer-bound nitric oxide-releasing compositions, pharmaceut Biopolymer-bound nitric oxide-releasing compositions, pharmaceut

1994-11-22

1997-05-27

Kulkosky, Peter F.

Drug, bio-affecting and body treating compositions

Solid synthetic organic polymer as designated organic active...

514 18, A61K 31785, A61K 3800

Patent

active

056329814

ABSTRACT:
A polymeric composition capable of releasing nitric oxide under physiological conditions which includes a biopolymer, such as a peptide, polypeptide, protein, oligonucleotide or nucleic acid, to which is bound a nitric oxide-releasing N.sub.2 O.sub.2.sup.- functional group; pharmaceutical compositions comprising the polymeric composition; and methods of treating biological disorders in which dosage with nitric oxide is therapeutic.

REFERENCES:
patent: 5155137 (1992-10-01), Keefer et al.
patent: 5250550 (1993-10-01), Keefer et al.
patent: 5405919 (1995-04-01), Keefer et al.
Stamler et al., "S-Nitrosylation of Proteins With Nitric Oxide: Synthesis and Characterization of Biologically Active Compounds," Proc. Natl. Aad. Sci. USA, 89:444-448 (1992).
Stamler et al., "S-Nitrosylation of Tissue-Type Plasminogen Activator Confers Vasodilatory and Antiplatelet Properties on the Enzyme," Proc. Natl. Acad. Sci. USA, 89:8087-8091 (1992).
Off-Line Bibliographic Citation List Generated by Medlars II regarding:Nitric:Release: or :Release:Nitric: (Excludes Proteins/Peptides (MH)).
Off-Line Bibliographic Citation List Generated by Medlars II regarding Nitric Oxide/Proteins/:Nitric:Release: or :Release:Nitric: (SENS).
Off-Line Bibliographic Citation List Generated by Medlars II regarding :Nitric:Donor: or :No:Donor: (SENS).
Off-Line Bibliographic Citation List Generated by Medlars II regarding Nitric Oxide/Peptides/:Nitric:Release: or :Release:Nitric.:.
Dialog Search Report regarding Nitric Oxide Complex(es).
Dialog Search Repot regarding Nitric Oxide and Rleas?.
Dialog Search Report regarding Nononate(s).

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