Biopolymer arrays and their fabrication

Chemistry: molecular biology and microbiology – Apparatus – Including measuring or testing

Reexamination Certificate

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C422S105000

Reexamination Certificate

active

06900048

ABSTRACT:
A method of fabricating an addressable array of biopolymers on a substrate using a biomonomer with a first linking group which must be activated for linking to a substrate bound moiety, and apparatus and computer program products for executing the method. The method includes forming on a region of the substrate carrying the substrate bound moiety, a solid activator composition. A biomonomer containing fluid composition is deposited on the region so that the solid activator activates the first linking group and the biomonomer links to the substrate bound moiety. The foregoing steps may be repeated, wherein a biomonomer deposited and linked to the substrate bound moiety in one cycle is the substrate bound moiety for the next cycle, so as to form the biopolymer.

REFERENCES:
patent: 4415732 (1983-11-01), Caruthers et al.
patent: 5449754 (1995-09-01), Nishioka
patent: 5700919 (1997-12-01), Seliger et al.
patent: 5807522 (1998-09-01), Brown et al.
patent: 5859233 (1999-01-01), Hirschbein et al.
patent: 5874554 (1999-02-01), Gamble et al.
patent: 5902878 (1999-05-01), Seliger et al.
patent: 5908926 (1999-06-01), Pirrung et al.
patent: 6001966 (1999-12-01), Pieken et al.
patent: 6184347 (2001-02-01), Perbost et al.
patent: 6300137 (2001-10-01), Earhart et al.
patent: WO 94/27719 (1994-12-01), None
patent: WO 95/25116 (1995-09-01), None
patent: WO 97/19749 (1997-06-01), None
patent: WO 98/41531 (1998-09-01), None
patent: WO 00/13796 (2000-03-01), None
Marshall, A., Hodgson, J., “DNA Chips: An Array of Possibilities”, Nature Biotechnology, vol. 16, pp. 27-31, 1998.
Pirrung, M.C., “Spatially Addressable Combinatorial Libraries”, Chem. Rev., vol. 97, pp. 473-488, 1997.
Pease et al., “Light-generated oligonucleotide arrays for rapid DNA sequence analysis”, Proceedings of the National Academy of Sciences, USA, vol. 91, pp. 5022-5026, 1994.
U.S. Appl. No. 09/972,256, filed Oct. 5, 2001, Earhart et al., titled, “Method for Synthesizing a Specific, Surface-Bound Polymer Uniformaly over an Element of a Molecular Array”.

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