Biopolymer and effector substance conjugates, process for the pr

Details Biopolymer and effector substance conjugates, process for the pr Biopolymer and effector substance conjugates, process for the pr

1994-02-24

1996-01-16

Ceperley, Mary E.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Stablizing an enzyme by forming a mixture, an adduct or a...

5303915, 5303919, 530404, C12N 996, C07K 1600

Patent

active

054847222

ABSTRACT:
The invention relates to compounds from biopolymers and effector substances which are linked with the aid of derivatives of optically active amino acids in which the amino group has been converted into a maleimido group and the carboxyl group into an active ester group, processes for the preparation thereof and the use thereof.

REFERENCES:
patent: 4868106 (1989-09-01), Ito et al.
M. Augustin et al., Journal f. prakt. Chemie., vol. 327, No. 5, pp. 857-864 (1985).
Keller et al., "Preparation and Some Properties of Maleimido Acids and Maleoyl Derivatives of Peptides", Helvetica Chimica Acta, 58(2):531-541 (1975).
Rich et al., "Alkylating Derivatives of Amino Acids and Peptides. Synthesis of N-Maleoylamino Acids, [1-(N-Maleoylglycyl)cysteinyl]oxytocin, and [1-(N-Maleoyl-11-aminoundecanoyl)cysteinyl]oxytocin. Effects on Vasopressin-Stimulated Water Loss from Isolated Toad Bladder", J. Med. Chem., 18:1004-1010 (1975).
Anderson et al., "The Use of Esters of N-Hydroxysuccinimide in Peptide Synthesis", J. Am. Chem. Soc., 86:1839-1842 (1964).
Ghose et al., "Preparation of Antibody-Linked Cytotoxic Agents", Methods in Enzymology, 93:280-333 (1983).
Ishikawa et al., "Enzyme Labeling of Antibodies and Their Fragments for Enzyme Immunoassay and Immunohistochemical Staining", J. Immunoassay, 4(3):209-237 (1983).

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