Biomolecules having multiple attachment moieties for binding...

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

Reexamination Certificate

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C536S025300, C536S025330, C435S006120

Reexamination Certificate

active

10181207

ABSTRACT:
Biomolecules are provided having multiple binding sites for attachment to a substrate surface. The multiple attachment sites may be produced directly on the biomolecule or through use of branched phosphoramidite moieties that can be added in multiple to form dendritic structures which can in turn provide attachment sites for substrate binding moieties. Substrate binding moieties may include noncovalent binding moieties. For covalent binding moieties oligonucleotides containing hydrazides are provided. These hydrazides can be introduced via protected building blocks such as phosphoramidites or via building blocks containing precursor forms of such hydrazides.

REFERENCES:
patent: 5476665 (1995-12-01), Dennison
patent: 5543054 (1996-08-01), Charkoudian et al.
patent: 5605662 (1997-02-01), Heller et al.
patent: 5807522 (1998-09-01), Brown et al.
patent: 5830655 (1998-11-01), Monforte et al.
patent: 5837859 (1998-11-01), Teoule et al.
patent: 5869466 (1999-02-01), Russell-Jones et al.
patent: 5929208 (1999-07-01), Heller et al.
patent: 5986076 (1999-11-01), Rothschild et al.
patent: 6011020 (2000-01-01), Gold et al.
patent: 0 361 768 (1990-04-01), None
patent: 0816368 (1998-01-01), None
patent: WO 85/05638 (1985-12-01), None
patent: WO 90/03401 (1990-04-01), None
patent: WO 00/29373 (2000-05-01), None
patent: WO 01/07657 (2001-02-01), None
patent: WO 01/09385 (2001-02-01), None
patent: WO 01/51689 (2001-07-01), None
Boullanger et al. J. Carbohydrate Chemistry 4(3), 279-291, 1985.
Beier, M., et al. “Versatile derivatisation of solid support media for covalent bonding on DNA-microchips.” Nucleic Acids Research 27(9): 1970-77 (1999).
Raddatz, S., et al. “Hydrazide oligonucleotides: new chemical modification for chip array attachment and conjugation.” Nucleic Acids Research 30(21): 4793-4802 (2002).
Timofeev et al., “Regioselective immobilization of short oligonucleotides to acrylic copolymer gels,”Nucleic Acids Research24(16):3142-3148.
Anderson & Kaplan. “Enzymatic Studies with Analogues of Diphosphopyridine Nucleotide.” Journal of Biological Chemistry 234(5): 1226-32 (1959).
Fehlhaber, H-W., et al. “Moenomycin A: A Structural Revision and New Structure-Activity Relations” Tetrahedron 46(5): 1557-68 (1990).
Ghosh, S., et al. “Synthesis of 5′ Oligonucleotide Hydrazide Derivatives and Their Use in Preparation of Enzyme-Nucleic Acid Hybridization Probes.” Analytical Biochemistry 178(1): 43-51 (1989).
Guzaev, A., et al. “Solid Support Synthesis of Ester Linked Hydrophobic Conjugates of Oligonucleotides.” Tetrahedron 55(30): 9101-9116 (Jul. 23, 1999).
Vogel, K.W., et al. “A Reversed Thioester Analogue of Acetyl-Coenzyme A: An Inhibitor of Thiolase and a Synthon for Other Acyl-CoA Analogues” J. Amer. Chem. Soc. 120(14): 3275-83 (Apr. 15, 1998).

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