Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2006-02-21
2006-02-21
Brusca, John (Department: 1631)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C435S005000, C435S006120, C435S180000, C536S023100, C536S024100
Reexamination Certificate
active
07002004
ABSTRACT:
Disclosed is a process to construct multi-component biomolecule or cellular arrays suitable for use in SPR imaging studies of large molecule, cellular/molecular, and cell/cell interactions. Also disclosed are the resulting arrays. The success of the procedure hinges on the use of a reversible protecting group to modify reversibly ω-functionalized alkanethiols self-assembled on metal substrates. The arrays themselves include a metal substrate, a continuous layer of an identical ω-modified alkanthiol adhered to the metal substrate, and one or more discrete spots of biomolecules or cells directly bonded to the continuous layer of ω-modified alkenthiol. The areas of the continuous layer of ω-modified alkenthiol not covered by one of the discrete spots are covered by a background material resistant to non-specific protein binding.
REFERENCES:
patent: 5242828 (1993-09-01), Bergström et al.
patent: 5347395 (1994-09-01), Lautenschlager et al.
patent: 5359681 (1994-10-01), Jorgenson et al.
patent: 5374563 (1994-12-01), Maule
patent: 5418136 (1995-05-01), Miller et al.
patent: 5436161 (1995-07-01), Bergström et al.
patent: 5468606 (1995-11-01), Bogart et al.
patent: 5482830 (1996-01-01), Bogart et al.
patent: 5492840 (1996-02-01), Malmqvist et al.
patent: 5494829 (1996-02-01), Sandstrom et al.
patent: 5541057 (1996-07-01), Bogart et al.
patent: 5550063 (1996-08-01), Bogart
patent: 5552272 (1996-09-01), Bogart
patent: 5554541 (1996-09-01), Malmqvist et al.
patent: 5583643 (1996-12-01), Gass et al.
patent: 5629213 (1997-05-01), Kornguth et al.
patent: 5629214 (1997-05-01), Crosby
patent: 5631171 (1997-05-01), Sandstrom et al.
patent: 5639671 (1997-06-01), Bogart et al.
patent: 5647030 (1997-07-01), Jorgenson et al.
patent: 5815278 (1998-09-01), Johnston et al.
patent: 5822073 (1998-10-01), Yee et al.
patent: 5835645 (1998-11-01), Jorgenson et al.
patent: 5858799 (1999-01-01), Yee et al.
patent: 5869272 (1999-02-01), Bogart et al.
patent: 6489102 (2002-12-01), Corn et al.
Brockman Jennifer M.
Corn Robert M.
Frutos Anthony G.
Brusca John
DeWitt Ross & Stevens S.C.
Leone, Esq. Joseph T.
Wisconsin Alumni Research Foundation
Zhou Shubo (Joe)
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