Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Solid support and method of culturing cells on said solid...
Reexamination Certificate
2008-07-01
2008-07-01
Sullivan, Daniel M (Department: 1636)
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
Solid support and method of culturing cells on said solid...
C435S325000, C435S373000, C435S395000, C435S401000
Reexamination Certificate
active
11184290
ABSTRACT:
A bio-artificial organ comprises a substrate comprising a roll of a substrate material, and a plurality of cells adhered to the substrate, the roll being formed from a sheet rolled to form a plurality of layers that include spacers and spaced openings such that at least a first set of parallel chambers is formed when the roll is formed, the chambers being manifolded to a first inlet and a first outlet. The bio-artificial organ may further include at least a second chamber, the second chamber being isolated from the first set of chambers by at least a cell barrier. A method for assembling a bio-artificial organ comprises a) providing a substrate for cell culture capable of forming a roll, the substrate having a surface, b) patterning the surface of the substrate, c) seeding cells onto the substrate, and d) reeling the substrate into a cylindrical roll.
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Carroll Rodney B.
Conley & Rose, P.C.
Sullivan Daniel M
William Marsh Rice University
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