Chemistry of inorganic compounds – Treating mixture to obtain metal containing compound – Radioactive metal
Patent
1985-03-05
1987-05-12
Terapane, John F.
Chemistry of inorganic compounds
Treating mixture to obtain metal containing compound
Radioactive metal
250432PD, 422159, 252645, C09K 1100, H01L 2500
Patent
active
046648925
ABSTRACT:
A method, composition of matter, and apparatus for producing substantially pure Ag-109m for use in biomedical imaging techniques. Cd-109, which decays with a half-life of 453 days to Ag-109m is loaded onto an ion exchange column consisting of particulate tin phosphate. After secular equilibrium is reached in about ten minutes, Ag-109m may be selectively eluted from the column by means of a physiologically acceptable aqueous buffered eluent solution of sodium thiosulfate, and either ascorbic acid or dextrose. The breakthrough of toxic Cd-109 is on the order of 1.times.10.sup.-7, which is sufficiently low to permit administration of the Ag-109m-containing eluate, with but a minor pH adjustment, directly to a human patient within a matter of seconds.
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Moody David C.
Steinkruger Frederick J.
Wanek Philip M.
Eklund William A.
Hightower Judson R.
Terapane John F.
The United States of America as represented by the United States
Wallen T. J.
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