Biomaterials with a base of mixtures of collagen, chitosan and g

Details Biomaterials with a base of mixtures of collagen, chitosan and g Biomaterials with a base of mixtures of collagen, chitosan and g

1989-02-15

1992-11-24

Doll, John

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530356, A61K 3712

Patent

active

051661870

ABSTRACT:
This biomaterial comprises at least a compound consisting of an association of collagen, chitosan acetylated to a degree of acetylation between about 10 and about 40% and of glycosaminoglycans.
It has its application in orthopedics and plastic surgery and for making extracellular matrices for regeneration of nerve cells and bones as well as biocompatible envelopes.
A particular application is the making of artificial skin consisting of a dermal layer of the velvet type obtained from biomaterials such as those described above.
The process of obtaining this dermal layer consists in adding a collagen solution of the chitosan, then in adding to the collagen-chitosan a mixture of chondroitins 4- and 6-sulfate.

REFERENCES:
patent: 4378017 (1983-03-01), Kosugi et al.
patent: 4448718 (1984-05-01), Yannas et al.
patent: 4784986 (1988-11-01), Usher
patent: 4808570 (1989-02-01), Michaeli

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