Biomarkers of metabolic responses to hepatic drugs

Details Biomarkers of metabolic responses to hepatic drugs Biomarkers of metabolic responses to hepatic drugs

2007-08-17

2010-10-05

Gitomer, Ralph (Department: 1657)

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

Testing efficacy or toxicity of a compound or composition

Reexamination Certificate

active

07807138

ABSTRACT:
Methods for the measurement and prediction of response to hepatotoxicants and carcinogens through the detection of metabolites in a mammal are provided. The metabolites can be used as biomarkers, including efficacy biomarkers, surrogate biomarkers, and toxicity biomarkers. The methods find use for early prediction of toxicity, target identification/validation, and monitoring of drug efficacy.

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