Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or...
Reexamination Certificate
2011-04-19
2011-04-19
Noakes, Suzanne M. (Department: 1656)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
C536S023100
Reexamination Certificate
active
07927788
ABSTRACT:
The present invention is directed toward biomarkers that identify characteristics of algae. The invention is further directed toward biomarkers that serve to identify algae species and strains of algae species as well as detect the presence of algal toxins. Additional embodiments feature methods utilizing algal biomarkers and polypeptides that can serve as biomarkers.
REFERENCES:
patent: 5223409 (1993-06-01), Ladner et al.
patent: 5283173 (1994-02-01), Fields et al.
patent: 5639611 (1997-06-01), Wallace et al.
patent: 5667973 (1997-09-01), Fields et al.
patent: 6083698 (2000-07-01), Olson et al.
patent: 6638719 (2003-10-01), Gunderson et al.
Anderson, et al. 1990. Dynamics and physiology of saxitoxin production by the dinoflagellatesAlexandriumspp.Marine Biology, 104:511-524.
Anderson, et al. 1990. Toxin composition variations in one isolate of the dinoflagellateAlexandrium fundyense. Toxicon, 28(8):885-893.
Anderson, D. M. Aug. 1994. Red tides.Scientific American, pp. 52-58.
Anderson, D. M. 1995. Identification of harmful algal species using molecular probes: An emerging perspective. In P. Lassus, et al. (Eds.),Harmful Marine Algal Blooms(pp. 3-13). New York: Lavoisier.
AOAC. 1990. Method 959.08, Paralytic shellfish poison. InOfficial Methods of Analyses, Association of Official Analytical Chemists, 15th Ed. (pp. 881-882). Arlington, VA.
Balech, E. 1995. The genusAlexandriumHalim (dinoflagellata), Sherkin Island Marine Station, Sherkin Island. p. 150.
Béchemin, et al. 1999. Effect of different nitrogen/phosphorus nutrient ratios on the toxin content inAlexandrium minutum. Aquatic Microbial Ecology, 20:157-165.
Boyer, et al. 1987. Effects of nutrient limitation on toxin production and composition in the marine dinoflagellateProtogonyaulax tamarensis. Marine Biology, 96:123-128.
Bram, et al. 1994. Calcium signalling in T cells stimulated by a cyclophilin B-binding protein.Nature, 371:355-358.
Bricelj, et al. 1990. Uptake ofAlexandrium fundyensebyMytilus edulisandMercenaria mercenariaunder controlled conditions. In E. Graneli, et al. (Eds.),Toxic Marine Phytoplankton(pp. 271-274). New York: Elsevier.
Carrell, et al. 1994. A novel procedure for the synthesis of libraries containing small organic molecules.Angew. Chem. Int. Ed. Engl., 33(20):2059-2061.
Carell, et al. 1994. A solution-phase screening procedure for the isolation of active compounds from a library of molecules.Angew. Chem. Int. Ed. Engl., 33(20):2061-2064.
Catterall, W. A. 1986. Molecular properties of voltage-sensitive sodium channels.Ann. Rev. Biochem., 55:953-985.
Chan, et al. 2004. Use of two-dimensional gel electrophoresis proteome reference maps of dinoflagellates for species recognition of causative agents of harmful algal blooms.Proteomics, 4:180-192.
Cho, et al. 1993. An unnatural biopolymer.Science, 261:1303-1305.
Cho, et al. 1998. Parallel analysis of genetic selections using whole genome oligonucleotide arrays.Proc. Natl. Acad. Sci. USA, 95:3752-3757.
Cook, et al. 2002. DNA microarrays: Implications for cardiovascular medicine.Circulation Research, 91:559-564.
Cull, et al. 1992. Screening for receptor ligands using large libraries of peptides linked to the C terminus of thelacrepressor.Proc. Natl. Acad. Sci. USA, 89:1865-1869.
Cwirla, et al. 1990. Peptides on phage. A vast library of peptides for identifying ligands.Proc. Natl. Acad. Sci. USA, 87:6378-6382.
Devlin, et al. 1990. Random peptide libraries: A source of specific protein binding molecules.Science, 249:404-406.
DeWitt, et al. 1993. “Diversomers”: An approach to nonpeptide, nonoligomeric chemical diversity.Proc. Natl. Acad. Sci. USA, 90:6909-6913.
Doucette, et al. 1998. Bacterial interactions with harmful algal bloom species: Bloom ecology, toxigenesis, and cytology. In D. M. Anderson, A. D. Cembella & G. M. Hallegraeff (Eds.),Physiological ecology of harmful algal blooms(pp. 619-647). Berlin: Springer-Verlag.
Erb, et al. 1994. Recursive deconvolution of combinatorial chemical libraries.Proc. Nati. Acad. Sci. USA, 91:11422-11426.
Felici, et al. 1991. Selection of antibody ligands from a large library of oligopeptides expressed on a multivalent exposition vector.J. Mol. Biol., 222:301-310.
Fields, et al. 1989. A novel genetic system to detect protein-protein interactions.Nature, 340:245-246.
Flynn, et al. 1996. Comparisons among species ofAlexandrium(Dinophyceae) grown in nitrogen- or phosphorus-limiting batch culture.Marine Biology, 126:9-18.
Fodor, et al. 1993. Multiplexed biochemical assays with biological chips.Nature, 364:555-556.
Franco, et al. 1994. Toxin profiles of natural populations and cultures ofAlexandrium minutumHalim from Galician (Spain) coastal waters.Journal of Applied Phycology, 6:275-279.
Frohman, et al. 1988. Rapid production of full-length cDNAs from rare transcripts: Amplification using a single gene-specific oligonucleotide primer.Proc. Natl. Acad. Sci. USA, 85:8998-9002.
Fromont-Racine, et al. 1997. Toward a functional analysis of the yeast genome through exhaustive two-hybrid screens.Nature Genetics, 16:277-282.
Gallop, et al. 1994. Applications of combinatorial technologies to drug discovery. 1. Background and peptide combinatorial libraries.Journal of Medicinal Chemistry, 37(9):1233-1251.
Harper, et al. 1993. The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases.Cell, 75:805-816.
Houghten, et al. 1992. The use of synthetic peptide combinatorial libraries for the identification of bioactive peptides.BioTechniques, 13(3):412-421.
Jellett, et al. 1992. Paralytic shellfish poison (saxitoxin family) bioassays: Automated endpoint determination and standardization of the in vitro tissue culture bioassay, and comparison with the standard mouse bioassay.Toxicon, 30(10):1143-1156.
Keller, et al. 1987. Media for the culture of oceanic ultraphytoplankton.J. Phycol., 23:633-638.
Lam, et al. 1991. A new type of synthetic peptide library for identifying ligand-binding activity.Nature, 354:82-84.
Lam, K. S. 1997. Application of combinatorial library methods in cancer research and drug discovery.Anti-Cancer Drug Design, 12:145-167.
Lawrence, et al. 2004. Quantitative determination of paralytic shellfish poisoning toxins in shellfish using prechromatographic oxidation and liquid chromatography with fluorescence detection: Interlaboratory study.Journal of AOAC International, 87(1):83-100.
Lichter, et al. 2000. Comparative genomic hybridization. Uses and limitations.Seminars in Hematology, 37(4):348-357.
Loeblich, A. R. III. 1984. Dinoflagellate physiology and biochemistry. In D. L. Spector (Ed.),Dinolagellates(pp. 299-342). Orlando: Academic Press.
MacBeath, et al. 2000. Printing proteins as microarrays for high-throughput function determination.Science, 289:1760-1763.
Maranda, et al. 1985. Comparison of toxicity between populations ofGonyaulax tamarensisof eastern North American waters.Estuarine, Coastal Shelf Science, 21:401-410.
McConnell, et al. 1992. The cytosensor microphysiometer: Biological applications of silicon technology.Science, 257:1906-1912.
Ogata, et al. 1989. Effect of water temperature and light intensity on growth rate and toxin production of toxic dinoflagellates. In T. Okaichi, et al. (Eds.),Red Tides: Biology Environmental Science and Toxicology(pp. 423-426). New York: Elsevier.
Ohara, et al. 1989. One-sided polymerase chain reaction: The amplification of cDNA.Proc. Natl. Acad. Sci. USA, 86:5673-5677.
Oshima, et al. 1989. Production of paralytic shellfish toxins by the dinoflagellateAlexandrium minutumHalim from Australia.Nippon Suisan Gakkaishi, 55(5):925.
Oshima, et al. 1993. Comparative study on paralytic shellfish toxin profiles of the dinoflagellateGymnodinium catenatumfrom three different countries.Marine Biology, 116:471-476.
Oshima, Y. 1995. Postcolumn derivatization liquid chromatographic method for paralytic shellfish toxins.Journal of AOAC International, 78(2):528-532.
Palenik, et al. 1998. Molecular markers of phytoplankton physiological status and their application at the level of individual cells. In K. E. Cooksey (Ed.),Molecular Approaches t
Chan Leo Lai
Hodgkiss Ivor John
Lo Samuel Chun-Lap
Noakes Suzanne M.
The Hong Kong Polytechnic University
Wang George G.
Wilkinson & Grist
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