Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2006-05-05
2009-10-20
Chernyshev, Olga N (Department: 1649)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S007800, C435S007900, C435S007920, C435S007940, C436S501000, C436S503000, C436S516000, C436S536000, C436S173000
Reexamination Certificate
active
07604948
ABSTRACT:
The present invention provides methods of identifying biomarkers indicative of the presence of a neurodevelopmental disorder, including an autism spectrum disorder, in an individual, using cytometry and mass spectrometry. The invention further provides methods of using the identified biomarkers to diagnose the presence of a neurodevelopmental disorder, including an autism spectrum disorder.
REFERENCES:
patent: 2004/0091943 (2004-05-01), Schneider
Spence et al., 2004, Semin. Pediatr. Neurol., 11, pp. 186-195.
Zipfel et al., 2002, Biochem Soc. Transactions, 30, pp. 971-978.
Raitanen et al., 1999, Scan. J. Urol. Nephrol., 33, pp. 234-236.
Donahue et al., 2004, Circulation, 110, No. 17, Suppl. III, 1011.
Corbett, et al., “A Proteomic Study of Serum From Children With Autism Showing Differential Expression of Apolipoproteins and Complement Proteins,”Molecular Psychiatry, (2007) 12, 292-306.
Ashwood, P., et al., “Spontaneous mucosal lymphocyte cytokine profiles in children with autism and gastrointestinal symptoms: mucosal immune activation and reduced counter regulatory interleukin-10,”J Clin Immunol, 24(6), 664-673 (2004).
Ashwood, P., et al., “A review of autism and the immune response,”Clinical and Developmental Immunology, vol. 11(2), 165-174 (Jun. 2004).
Ashwood, P., et al., “Is autism an autoimmune disease?”Autoimmune Rev., vol. 3(7-8), 13 pgs. (Nov. 2004).
Cantor, R., et al., “Replication of autism linkage: fine-mapping peak at 17q21,”Am J Hum Genet, 76(6), 1050-1056 (2005).
Croen, L., et al., “Maternal autoimmune diseases, asthma and allergies, and childhood autism spectrum disorders,”Arch. Pediatr. Adolesc Med., vol. 159, 151-157 (Feb. 2005).
DeFelice, M., et al., “Intestinal cytokines in children with pervasive developmental disorders,”Am J Gastroenterol., 98(8), 1777-1782 (2003).
Ferrante, P., et al., “Significant association of HLA A2-DR11 with CD4 naive decrease in autistic children,”Biomed Pharmacother., 57(8), 372-374 (2003).
Geschwind, D., et al., “The autism genetic resource exchange: a resource for the study of autism and related neuropsychiatric conditions,”Am J Hum Genet., 69(2), 463-466 (2001).
Jyonouchi, H., et al., “Evaluation of an association between gastrointestinal symptoms and cytokine production against common dietary proteins in children with autism spectrum disorders,”J Pediatr., 146(5), 605-610 (2005).
Jyonouchi, H., et al., “Innate immunity associated with inflammatory responses and cytokine production against common dietary proteins in patients with autism spectrum disorder,”Neuropsychobiology., 46(2), 76-84 (2002).
Jyonouchi, H., et al., “Proinflammatory and regulatory cytokine production associated with innate and adaptive immune responses in children with autism spectrum disorders and developmental regression,”J Neuroimmunol., 120(1-2), 170-179 (2001).
McCauley, J., et al., “Genome-wide and Ordered-Subset linkage analyses provide support for autism loci on 17q and 19p with evidence of phenotypic and interlocus genetic correlates,”BMC Med Genet., 6, 1 (2005).
Molloy, C., et al., “Elevated cytokine levels in children with autism spectrum disorder,”J Neuroimmunol, 14 (2005).
Odell, D., et al., “Confirmation of the association of the C4B null allelle in autism,”Hum Immunol., 66(2), 140-145 (2005).
Purcell, A., et al., “The abnormal regulation of gene expression in autistic brain tissue,”J Autism Dev Disord, 31(6), 545-549 (2001).
Risch, N., “Searching for genetic determinants in the new millennium,”Nature, 405(6788), 847-856 (2000).
Risch, N., et al., “A genomic screen of autism: evidence for a multilocus etiology,”Am J Hum Genet, 65(2), 493-507 (1999).
Segurado, R., et al., “Confirmation of Association Between Autism and the Mitochondrial Aspartate/Glutamate Carrier SLC25A12 Gene on Chromosome 2q31,”Am J Psychaiatry, 162(11), 2182-2184 (2005).
Singh, V., “Plasma increase of interleukin-12 and interferon-gamma. Pathological significance in autism,”J Neuroimmunol., 66(1-2), 143-145 (1996).
Singh, et al., “Prevalence of serum antibodies to caudate nucleus in autistic children,”Neuroscience Letters, vol. 355, 53-56 (2004).
Torres, A., et al., “The association of MHC genes with autism,”Front Biosci, 6, D936-943 (2001).
Torres, A., et al., “The transmission disequilibrium test suggests that HLA-DR4 and DR13 are linked to austism spectrum disorder,”Hum Immunol., 63(4), 311-316 (2002).
Torres, A., et al., “ Is fever suppression involved in the etiology of autism and neurodevelopmental disorders?”BMC Pediatrics, vol. 3(9), pp. 1-6 (2003).
Vargas, D., et al., “Neuroglial activation and neuroinflammation in the brain of patients with autism,”Ann. Neurol., vol. 57, 67-81 (2005).
Vorstman, J., et al., “Identification of novel autism candidate regions through analysis of reported cytogenetic abnormalities associated with autism,”Mol Psychiatry, 4 (2005).
Van Gent, T., et al., “Autism and the immune system,”J Child Psychol Psychiatry, 38(3), 337-349 (1997).
Warren, R., et al., “Strong association of the third hypervariable region of HLA-DR beta 1 with autism,”J Neuroimmunol., 67(2), 97-102 (1996).
Warren, R., et al., “Immunogenetic studies in autism and related disorders,”Mol Chem Neuropathol., 28(1-3), 77-81 (1996).
Warren, R., et al., “DR-positive T cells in autism: association with decreased plasma levels of the complement C4B protein,”Neuropsychobiology., 31(2), 53-57 (1995).
Wassink, T., et al., “The search for autism disease genes,”Ment Retard Dev Disabil Res Rev., 10(4), 272-283 (2004).
Zimmerman, A., et al., “Cerebrospinal fluid and serum markers of inflammation in autism,”Pediatr Neurol., 33(3), 195-201 (2005).
Amaral David G.
Corbett Blythe A.
Chernyshev Olga N
The Regents of the University of California
Townsend and Townsend / and Crew LLP
LandOfFree
Biomarkers for diagnosing an autism spectrum disorder does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Biomarkers for diagnosing an autism spectrum disorder, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Biomarkers for diagnosing an autism spectrum disorder will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4094462