Biomarker for farnesyl pathway

Chemistry: analytical and immunological testing – Peptide – protein or amino acid – Amino acid or sequencing procedure

Reexamination Certificate

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C436S086000, C436S106000, C436S119000

Reexamination Certificate

active

08084262

ABSTRACT:
The invention generally provides methods to determine the extent to which a compound interferes with steroid metabolism, comprising a novel biomarker of a felinine derivative. The invention also provides such novel felinine derivative biomarker.

REFERENCES:
Hendriks et al. “Isolation and characterisation of renal metabolites of gamma-glutamylfeinylglycine in the urine of the domestic cat (Felis catus)”. 2004. Comparative Biochemistry and Physiology, Part B. vol. 139. pp. 245-251.
Daniels et al, “One-pot synthesis of L-felinine” Tetrahedron Letters 1999, 40, 4463-4465.
Hendriks et al., “Felinine: A Urinary Amino Acid of Felidae”, Comparative Biochemistry and Physiology, vol. 112B, No. 4, pp. 581-588 (1995).
Reszka et al., “Nitrogen-Containing Bisphosphonate Mechanism of Action”, Mini Reviews in Medicinal Chemistry, vol. 4, No. 7, pp. 711-719 (2004).

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