Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2011-08-02
2011-08-02
Cheu, Jacob (Department: 1641)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S007200, C436S518000
Reexamination Certificate
active
07989174
ABSTRACT:
The invention relates to the following methods [1] to [3] and to a kit for carrying out the methods:[1] a method for detecting heart disease, characterized in that the method comprises determining a free immunoglobulin kappa light chain level and/or a free immunoglobulin lambda light chain level of a specimen and comparing at least one value of the kappa chain level, the lambda chain level, and a kappa/lambda ratio with that of a healthy subject;[2] a method for detecting a complication of viral infection in a patient with heart disease, characterized in that the method comprises determining a free immunoglobulin kappa light chain level and/or a free immunoglobulin lambda light chain level of a specimen and comparing at least one value of the kappa chain level, the lambda chain level, and a kappa/lambda ratio with that of a healthy subject;[3] A method for detecting severity of heart disease, characterized in that the method comprises determining a free immunoglobulin kappa light chain level and/or a free immunoglobulin lambda light chain level of a specimen and comparing at least one value of the kappa chain level, the lambda chain level, and a kappa/lambda ratio with that of a healthy subject or a patient suffering slight heart disease.
REFERENCES:
patent: 4800155 (1989-01-01), Taniguchi et al.
Fisher, Christian et al., “Kappa Free Light Chains in Cerebrospinal Fluid as Markers of Intrathecal Immunoglobulin Synthesis”, Clinical Chemistry, vol. 50, No. 10, pp. 1809-1813, 2004.
Katzmann, Jerry A. et al., “Serum Reference Intervals and Diagnostic Ranges for Free K and Free Λ Immunoglobulin Light Chains: Relative Sensitivity for Detection of Monoclonal Light Chains”, Clinical Chemistry, vol. 48, No. 9, pp. 1437-1444, 2002.
Bollengier, Francine, “Bound and Free Light Chains in Serum from Patients Affected with Various Neurological Diseases”, J. Clin.Chem.Clin.Biochem., vol. 17, pp. 45-49, 1979.
Contini, Carlo et al., “Evidence of Cerebrospinal Fluid Free Kappa Light Chains in AIDS patients with Toxoplasma gondii encephalitis”, Journal of Neuroimmunology, vol. 108, pp. 221-226, 2000.
Dubrey S.W., et al., “The clinical features of Immunoglobulin light-chain (AL) amyloidosis with heart involvement”, Monthly Journal of the Association of Physicians, vol. 91, No. 2, Feb. 1998, p. 141-157.
Sanchorawala, Vaishali, et al., “Pulsed Low Dose Intravenous Melphalan in Patients with AL Amyloidosis, Ineligible for Aggressive Treatment with High-Dose Melphalan and Stem Cell Transplantation”, Blood (ASH Annual Meeting Abstracts), vol. 4, No. 11, Part 1, Nov. 2004.
Hsu, J.Y., et al., “The Clinicopathological Specturm of Renal Amyloidosis”, Zhonghua Yi Xue Za Zhi = Chinese Medical Journal; Free China ed, vol. 54, No. 4, Oct. 1994, pp. 230-239.
Burkhardt, O., et al., “Diagnosis of multiple myeloma by demonstrating plasma cells in bronchoalveolar lavage”, DMW Deutsche Medizinische Wochenschrift, vol. 128, No. 38, Sep. 19, 2003, pp. 1951-1954.
Nakano, T., et al., “Elisas for free human immuniglobulin light chains in serum: improvement of assay specificity by using two specific antibodies in a sandwich detection method”, Journal of Immunological Methods, vol. 293, No. 1-2, Oct. 1, 2004, pp. 183-189.
“Free Immunoglobulin Light-Chains as a New Biomarker of Heart Failure” Journal of Cardial Failure, vol. 11, No. 6, Aug. 1, 2005, p. S121.
Falk, Rodney H., “Diagnosis and Management of the Cardiac Amyloidoses”, Circulation, vol. 112, No. 13, Sep. 27, 2005, pp. 2047-2060.
Motoyuki Nakamura, et al., “Reversible Restrictive Cardiomyopathy Due to Light-Chain Deposition Disease”, Mayo Clin Proc., Mayo Foundation for Medical Education and Research, vol. 77, Feb. 2002, pp. 193-196.
Wong et al., Cardiovascular Pathology 2004, vol. 13, p. 49-53.
Garton et al., Postgrad Med J, 1993, vol. 69, pp. 588-591.
Kyriakides et al., Clinical neuropath, 2001, vol. 21, pp. 145,148.
Cheu Jacob
Oblon, Spivak McClelland, Maier & Neustadt, L.L.P.
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