Chemistry: molecular biology and microbiology – Apparatus – Including measuring or testing
Reexamination Certificate
2011-01-11
2011-01-11
Lilling, Herbert J. (Department: 1657)
Chemistry: molecular biology and microbiology
Apparatus
Including measuring or testing
C435S018000, C435S032000
Reexamination Certificate
active
07867758
ABSTRACT:
A bioluminogenic assay system including: providing a bioluminogenic substrate incorporating a beta-lactam antibiotic, a bioluminescence initiating compound, and a chemical linkage joining the beta-lactam antibiotic to the bioluminescence initiating compound; exposing the bioluminogenic substrate to a beta-lactamase enzyme that catalyzes the release of the bioluminescence initiating compound from the bioluminogenic substrate; co-exposing the bioluminogenic substrate to a bioluminescence indicator reaction that employs the bioluminescence initiating compound as a substrate; and detecting a light from the bioluminescence indicator reaction as a measure of the activity of the beta-lactamase enzyme.
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Rao Jianghong
So Min-kyung
Yao Hequan
Ishimaru Mikio
Lilling Herbert J.
The Board of Trustees of the Leland Stanford Junior University
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