Biologically mimetic synthetic ion channel transducers and metho

Details Biologically mimetic synthetic ion channel transducers and metho Biologically mimetic synthetic ion channel transducers and metho

1994-09-27

1996-05-14

Schain, Howard E.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

15 to 23 amino acid residues in defined sequence

530327, 530328, 530329, 530330, 530331, A61K 3804, C07K 700, C07K 500

Patent

active

055168906

ABSTRACT:
The invention relates to synthetic proteins that can be used in in vitro sensing devices to detect the presence of physiologically active substances. The synthetic proteins are mimetic to native ion channels in mammalian systems. The invention also relates to a biosensor comprising a support assembly, a synthetic lipid bilayer containing the active channel protein. Lastly, the invention relates to the use of the biosensor disclosed in the application for the in vitro detection of physiologically active substances including antiseptics, antibiotics, neurotransmittors, and others.

REFERENCES:
Oiki, S. et al. (1988) M2 delta, a candidate for the structure lining the ionic channel of the nicotinic cholinergic receptor. Proc. Natl. Acad. Sci. USA 85, 8703-8707. See entire article; sequence of Torpedo AcChoR delta subunit in abstract and Fig. 1A Available to public Nov. 18, 1988.
Stewart, J. et al. "Solid Phase Peptide Synthesis", 2nd Ed. Pierce Chemical Co., Rockford, IL, 1984, see pp. 1-49.

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