Biologically degradable superparamagnetic particles for use as n

Details Biologically degradable superparamagnetic particles for use as n Biologically degradable superparamagnetic particles for use as n

1986-07-03

1988-09-13

Rosenbaum, C. Fred

Surgery

Truss

Pad

600 12, 424 9, A61B 600

Patent

active

047701838

ABSTRACT:
This invention relates to an improved method for obtaining the in vivo MNR image of an organ or tissue of an animal or human subject. More specifically, this invention relates to the use of small (about 10 to about 5,000 angstroms in diameter) biodegradable superparamagnetic metal oxide particles for use as imaging agents. The particles, which may be uncoated or surrounded by a stable polymeric coating, can be mixed with a physiologically acceptable medium to form a uniform dispersoid which can be administered to the subject by a variety of routes. Once administered, the particles collect in the target organ or tissue where they will remain for a time sufficiently long for an image to be obtained, but are ultimately metabolized or cleared within about 7 days.

REFERENCES:
patent: Re27240 (1971-11-01), London et al.
patent: 2820740 (1958-01-01), London et al.
patent: 2862920 (1958-12-01), Berger et al.
patent: 2971916 (1961-02-01), Schleichter et al.
patent: 3093545 (1963-06-01), Westfal et al.
patent: 3100202 (1963-08-01), Muller et al.
patent: 3190837 (1985-06-01), Brynko et al.
patent: 3228881 (1966-01-01), Thomas
patent: 3234209 (1966-02-01), Floramo
patent: 3275514 (1966-09-01), Saltman
patent: 3474777 (1969-10-01), Figge et al.
patent: 3480555 (1969-11-01), Jackson et al.
patent: 3531413 (1970-09-01), Rosensweig
patent: 3700595 (1972-10-01), Kaiser
patent: 3832457 (1974-08-01), Sugimoto et al.
patent: 3843540 (1974-10-01), Reimers et al.
patent: 3870645 (1975-03-01), Frei et al.
patent: 3928581 (1975-12-01), Dahlberg et al.
patent: 4001288 (1977-01-01), Gable et al.
patent: 4019994 (1977-04-01), Kelley
patent: 4025448 (1977-05-01), Sudol
patent: 4101435 (1978-07-01), Hasegawa et al.
patent: 4136683 (1979-01-01), Gordon
patent: 4230685 (1980-10-01), Senyei et al.
patent: 4247406 (1981-01-01), Widder et al.
patent: 4269826 (1981-05-01), Zimmermann et al.
patent: 4331654 (1982-05-01), Morris
patent: 4345588 (1982-02-01), Widder et al.
patent: 4356098 (1982-10-01), Chagnon
patent: 4357259 (1982-11-01), Senyei et al.
patent: 4452773 (1984-06-01), Molday
patent: 4501726 (1985-02-01), Schroder et al.
patent: 4615879 (1986-10-01), Runge et al.
patent: 4637929 (1987-01-01), Quay
patent: 4656026 (1987-04-01), Coffman et al.
patent: 4675173 (1987-06-01), Widder
Saini, S. et al., Radiology (1987) 162, 217.
Widder, D. J. et al., Amer. J. Roentgenol (1987) 148, 399.
Olsson, M. B. E. et al., Magnetic Resonance Imaging (1986) 4, 142.
Weiss, R. D. et al., J. Appl. Phys. (1985) 57, 4274.
Welo, L. A.; Baudisch, O. Chem. Rev. (1934) 15, 45.
Kaiser, R.; Miskolszy, G. 1970 Intermag Conference, Washington, D.C., Apr. 21-24.
Elmore, W. C. Physical Rev. (1938) 54, 1092.
Koch, A. J.; Becker, J. J. J. Appl. Phys. (1968) 39, 1261.
Elmore, W. C. Physical Rev. (1937) 51, 982.
McKeehan, L. W.; Elmore, W. C. Physical Rev. (1934) 46, 226.
Bancroft, W.D. Appl. Coll. Chem., Gen. Theory, 3rd Ed. (1932).
Travis, P. M. Mechanochemistry and the Colloid Mill Including the Practical Applications of Fine Dispersion (1928) Book Dept., Chem., Cat. Co., Inc.
Driscoll, C. F. et al. Microvas, Res. (1984) 27, 353.
Senyei, A. E. et al. Metho. Enzymol (1985) 112, 56.
Ohgushi, M. et al. J. Magnetic Resonance (1978) 29, 599.
Renshaw, P. F. et al., Mag. Resonan in Medicine (1986) 3, 217.
Lauffer, R. B. et al., J. Comput. Assist. Tomography (1985) 9(3), 431.
Dias, M. H. M.; Lauterbur, P. C. Mag. Reson. in Medicine (1986) 3, 328.
Brasch, R. C. Radiology (1983) 147, 781.
Wolf, G. L. Magnetic Resonance Annual 1985, p. 231.
Weinmann, H. J. et al. Amer. J. Roentgenol. (1984) 142.
Runge, P. M. et al., Radiology (1983) 147, 789.
Greif, W. L. Radiology (1985) 157, 461.
Wesberg, G. E. et al., Radiology (1983) 149, 175.
Kaiser, R.; Miskolczy, G. J. Appl. Phys. (1970) 41, 1064.
Elmore, W. C. Physical Rev. (1938) 54, 309.
Shliomis, M. I., Sov. Phys. Usp. (1974) 17, 153.
Cox, J. S. G. et al., J. Pharm. Pharmac. (1972) 24, 513.
Marshall, P. R.; Rutherford, D. J. Coll. Interface Sci. (1971) 37, 390.
Ricketts, C. R. et al. Nature (1965) 5007, 237.
Muller, A. Arzheim, Forsch. (1967) 17, 921.
Bersin, T. Pharm. Acta Helv. (1964) 39, 657.
Widder, K. J. et al. Eur. J. Can. Clin. Oncol. (1983) 19, 135.
Widder, K, et al. J. Pharm. Sci. (1979) 68 79.
Molday et al., "Application of Magnetic Microspheres in Labeling and Separation of Cells" in Nature, vol. 268, 4 Aug. 1977, pp. 437-438.
Newbauer ,"Magnetic Fluids in the Blood" in IGGG Transactions and Magnetics, vol. 9, No. 3, Sep. 1973, pp. 447-450.
Gore et al., "Nuclear Magnetic Resonance (NMR) Imaging at Hamersmith Hospital" in SPIE, vol. 273, Optical Instrumentation in Medicine (IX), 1981, pp. 8-10.

Affiliated with

Also associated with

Rating

Biologically degradable superparamagnetic particles for use as n does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Biologically degradable superparamagnetic particles for use as n, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Biologically degradable superparamagnetic particles for use as n will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-800815