Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1985-03-29
1987-09-29
Marantz, Sidney
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514265, 514 17, 514 18, 514 19, 544269, 544271, 544273, 530330, 530331, 530332, 2609982, A61K 3152, C07D47306
Patent
active
046969322
ABSTRACT:
Certain functionalized cogeners of 1,3-dialkylxanthine exhibit high potency and selectivity as antagonists for A.sub.1 - and A.sub.2 -adenosine receptors and are suitable for attachment to probes, drug carriers, or solid supports. These derivatives are characterized by the presence of a phenyl at the 8 position para-substituted with a functionalized chain to provide high water solubility and high receptor affinity. Some of these analogs, containing a distal amino- or carboxylic-functionalized chain, are suitable for synthesis of amino acid conjugates. The compounds of this invention are suitable for use as antiallergenic, antiasthmatic, or cardiotonic drugs, central nervous system stimulants, and diuretics.
REFERENCES:
patent: 4397779 (1983-08-01), Groman
Bruns, Proc. Natl. Acad. Sci., (USA), 80, pp. 2077-2080 (4/83).
Daly John W.
Jacobson Kenneth A.
Kirk Kenneth L.
Benson Robert
Marantz Sidney
Roberts, Jr. John S.
The United States of America as represented by the Department of
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