Drug – bio-affecting and body treating compositions – Extract – body fluid – or cellular material of undetermined... – Milk or colostrum
Patent
1989-10-04
1994-03-01
Robinson, Douglas W.
Drug, bio-affecting and body treating compositions
Extract, body fluid, or cellular material of undetermined...
Milk or colostrum
514 2, 514 21, 514251, 514276, 514885, 530365, 530833, 426 72, A61K 3520
Patent
active
052905713
ABSTRACT:
The present invention is concerned with a whey protein composition comprising a suitable concentration of whey protein concentrate wherein the whey protein concentrate contains proteins which are present in an essentially undenatured state and wherein the biological activity of the whey protein concentrate is dependent on the overall amino acid and small peptides pattern resulting from the contribution of all its protein components and a method of producing said whey protein composition. The invention also relates to several applications of said composition.
REFERENCES:
patent: 4043990 (1977-08-01), Melachouris
patent: 4485040 (1984-11-01), Roger et al.
patent: 4497836 (1985-02-01), Marquardt et al.
patent: 4784685 (1988-11-01), Meister
Baricelli, G. C.: De seri facultatibus, et usu, opusculum secundum, Scorriggium, Publ. Naples, Italy, pp. 105-147, 1603.
Cantani, A.: Latte e siero di latte in-Materia medica e terapeutica-vol. 1-Vallardi F. Publ., Milano, Italy, p. 385, 1869.
Hoffman, K. F.: Zur geschichte der molkenkuren, insbesondere im 17, 18 und 19 Jahrhundert. Med. Monatschr 15: 411-416, 1961.
Barness, L. A., et al.: Progress of premature infants fed a formula containing demineralized whey. Pediatrics, Jul. 1963, pp. 52-55.
Raiha, N. C. R., et al.: Milk protein quantity and quality in low birth weight infants I. Metabolic responses and effects on growth. Pediatrics 57:659-674, 1976.
Rassin D. K. et al.: Milk protein quantity and quality in low birth weight infants. J. Pediat. 90: 356-360, 1977.
Berger, H. M., et al: Curd and whey proteins in the nutrition of low birth weight babies. Arch. Dis. in Child. 54: 98-104, 1979.
Mietens, C. et al.: Treatment of infantile E. coli gastroenteritis with specific bovine anti-E. coli milk immunoglobulins. Europ. J. Pediatr. 132: 239-252, 1979.
Bounous, G. et al: Influence of dietary lactalbumin hydrolysate on the immune system of mice and resistance to Salruonellosis. J. Infect. Dis. 144: 281, 1981.
Williamson, J. M. et al: Stimulation of hepatic gluathione formation by administration of L-2-oxothiazolidine-4-carboxylate, a 5-oxo-L-prolinase substrate. Proc. Natl. Acad. Sci. (USA) 78: 936-939, 1981.
Williamson, J. M. et al: Intracellular cysteine delivery system that protects against toxicity by promoting GSH synthesis. Proc. Natl. Acad. 79: 6246-6249, 1982.
Bounous, G. et al.: Influence of dietary proteins on the immune system of mice. J. Nutr. 112: 1747-1755, 1982.
Birt, D. et al: Nutritional evaluation of three dietary levels of lactalbumin throughout the lifespan of two generations of Syrian hamsters. J. Nutr. 112: 2151-2160, 1982.
Birt, D. F., et al.: Survival of hamsters fed graded levels of two protein sources. Lab. Animal Sci. 32: 363-366, 1982.
Bounous, G. et al.: Influence of dietary protein type on the immune system of mice. J. Nutr. 113: 1415-1421, 1983.
Volz, V. R. et al: Growth and plasma amino acid concentrations in term infants fed either whey-predominant formula or human milk. J. Pediatr. 102: 27-31, 1983.
Esterela, J. M. et al: The effect of cysteine and N-acetylcysteine on rat liver glutathione. Biochem. Pharmacol. 32: 3483-3485, 1983.
Anderson, M. E. et al: Transport and direct utilization of gamma-glutamylcysteine for glutathione synthesis. Proc. Natl. Acad. Sci. (USA) 80: 707-711, 1983.
Puri, R. N. et al: Transport of glutathione as gamma-glutamylcysteinyl-glycylester into liver and kidney. Proc. Natl. Acad. Sci. (USA) 80: 5258-5260, 1983.
Janas, L. M. et al: Indices of protein metabolism in term infants fed human milk, whey predominant formula or cow's milk formula. Pediatrics 75: 775-784, 1985.
Darling, P. et al: Protein quality and quantity in preterm infants receiving the same energy intake. Am. J. Dis. of Child. 139: 186-190, 1985.
Bounous, G. et al: Mechanism of altered .beta.-cell response induced by changes in dietary protein type in mice. J. Nutr. 115: 1409-1417, 1985.
Shenai, J. P. et al: Nutritional balance studies in very low birth weight infants: role of whey formula. J. Ped. Gastr. and Nutr. 5: 428-433, 1986.
Lauterburg, B. H. et al: Therapeutic doses of acetaminophen stimulate the turnover of cysteine and glutathione in man. J. Hepat. 4: 206-211, 1987.
Bounous, G., et al: Dietary whey protein inhibits the development of dimethylhydrazine induced malignancy. Clin. Invest. Med. 11: 213-217, 1988.
Tacket, C. O. et al: Protection by milk immunoglobulin concentrate against oral challenge with enterotoxigenic Escherichia Coli. New Engl. J. Med. 318: 1240-1243, 1989.
Taylor, Y. C. et al: Elevation of intracellular glutathione levels following depletion and its relationship to protection against radiation and alkylating agents. Pharmacology Ther. 39: 293-299, 1988.
White, C. W. et al: Hypoxia increases glutathione redox cycle and protects rat lungs against oxidants. J. Appl. Physiol 65: 2607-2616, 1988.
Bounous, G. et al: The immunoenhancing property of dietary whey protein concentrate. Clin. Invest. Med. 121: 271-278, 1988.
Bounous, G. et al: Influence of protein type in nutritionally adequate diets on the development of immunity in "Absorption and utilization of amino acids". C.R.C. Press, Ed. M. Friedman, pp. 219-232, 1989.
Bounous, G. et al: Immunoenhancing property of dietary whey protein in mice: role of glutathione. Clin. Invest. Med. 12: 154-161, 1989.
Papenburg, R. et al: Dietary milk proteins inhibit the development of dimethylhydrazine induced malignancy. In press, Tumor Biology.
Schaedler, R. W., et al: Effect of dietary proteins and amino acids on the susceptibility of mice to bacterial infections. J. Exp. Med. 110: 921-934, 1959.
Hirayama, T.: An epidemiological study on the effect of diet, especially of milk, on the incidence of stomach cancer. Abstr. 9th Int. Cancer Congress, Tokyo, Japan 713, 1966.
Jacquet, J. et al: Nutrition et cancer experimental: cas du lait. C. R. Hebd. Seanc. Acad. de France, 54: 112-120, 1968.
I.A.R.C. International microecology group. Dietary fiber, transit-time, fecal bacteria steroids, and colon cancer in two Scandinavian populations. Lancet II, 207-211, 1977.
Gridley, D. S. et al: Modification of Herpes 2-transformed cell-induced tumors in mice fed different sources of protein fat and carbohydrate. Cancer Letters 17: 161-173, 1982.
Nutter, R. L. et al: Modification of a transplantable colon tumor and immune responses in mice fed different sources of protein, fat and carbohydrate. Cancer Letters 18: 49-62, 1983.
Nutter, R. L. et al: BALB/c male mice fed milk or beef protein: Differences in response to 1,2-dimethylhydrazine carcinogenesis. J.N.C.I. 71: 867-874, 1983.
Reddy, G. V., et al: Antitumor activity of yogurt components. J. Food Protection 46: 8-11, 1983.
Tsuru, S. et al: Inhibition of tumor growth by dairy products. J. Clin. Lab. Immunol. 25: 177-183, 1988.
Perdigon, G. et al: Systemic augmentation of the immune response in mice by feeding fermented milks with Lactobacillus casei and Lactobacillus acidophilus. Immunology 63: 17-23, 1988.
K. R. Marshall, "Industrial Isolation of Milk Proteins: Whey Proteins," Developments in Dairy Chemistry (P. F. Fox, ed.), Appl. Sci. Publ., N.Y.:339-373(1982) (Exhibit A).
Rodney J. Brown, "Milk Coagulation and Protein Determination," Fundamentals of Dairy Chemistry (N. P. Wong, ed.), Van Nostrand Reynolds Co., N.Y.:583-607,(1988) (Exhibit B).
R. McL. Whitney, "Proteins of Milk," Fundamentals of Dairy Chemistry (N. P. Wong, ed.), Van Nostrand Reynolds Co., NY: 81-169 (1988) (Exhibit C).
Bounous Gustavo
Gold Phil
Kongshavn Patricia A. L.
Immunotec Research Corporation Ltd.
Robinson Douglas W.
White John P.
Witz Jean C.
LandOfFree
Biologically active whey protein concentrate does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Biologically active whey protein concentrate, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Biologically active whey protein concentrate will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-575347