Biologically active ureido derivatives useful as anit-metastic a

Details Biologically active ureido derivatives useful as anit-metastic a Biologically active ureido derivatives useful as anit-metastic a

1995-06-12

1996-07-09

McKane, Joseph K.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548518, A61K 31395

Patent

active

055345395

ABSTRACT:
The invention relates to the use of compounds of formula (I) ##STR1## wherein each of m and n, being the same, is an integer of 1 to 3; and each of the R groups, which are the same, is a naphthyl group substituted by 1 to 3 sulfonic groups,or pharmaceutically acceptable salts thereof, in the preparation of a medicament for use in preventing and/or treating the metastatic spread of tumors.

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Sola et al, International Symposium on Angiogenesis, St. Gallen (Switzerland) Mar. 1991, Abstracts, Abstract No. 90.
Drug Design and Recovery, vol. 8, No. 1, 1991, pp. 3-35, D. C. Billington, "Angiogenesis and its Inhibition: Potential New Therapies In Oncollogy and Non-Neoplastic Diseases".
Cancer Research, vol. 52, No. 23, Dec. 1, 1992, pp. 6702-6704, B. Teicher, et al., "Antiangiogenic Agents Potentiate Cytotoxic Cancer Therapies Against Primary and Metastatic Disease".
CA 115(19):207848w Preparation of . . . --methlpyrroles, Mongelli et al., 1991.

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