Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1992-03-13
1993-11-16
Rotman, Alan L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
546124, C07D45106, C07D45104, A61K 3146
Patent
active
052624285
ABSTRACT:
Preparation of biologically active tropane derivatives of novel configurations. The compounds are prepared by decomposing vinyldiazomethanes in the presence of pyrroles to provide a bicyclic ring containing the basic tropane ring system which is then reacted with an aryl Grignard reagent in the presence of a copper (I) or (II) salt to provide 3-aryltropane derivatives.
REFERENCES:
patent: 3120537 (1964-02-01), Archer et al.
patent: 3813404 (1974-05-01), Clarke et al.
Boja, et al., "New, Potent Cocaine Analogs: Ligand Binding and Transport Studies in Rat Striatum", European Journal of Pharmacology, 184 (1990) 329-332.
Carroll, et al., "Synthesis, Ligand Binding, QSAR and CoMFA Study of 3.beta.-Carboxylic Acid Methyl Esters", Journal of Medicinal Chemistry, vol. 34, No. 9 (1991), pp. 2719-2725.
Clarke, et al., "Compounds Affecting the Central Nervous System. 4. 3.beta.-Phenyltropane-2-Carboxylic Esters and Analogs", Journal of Medicinal Chemistry, vol. 16, No. 11 (1973) pp. 1260-1267.
"Synthesis of (.+-.)-Ferruginine and (.+-.)-Anhydroecgonine Methyl Ester By a Tandem Cyclopropanation/Cope Rearrangement", J. Org. Chem., vol. 56, No. 19 (1991) p. 5696-5700.
Madras, et al., "Cocaine Receptors Labeled by [.sup.3 H]2.beta.-(4-Fluorophenyl) Tropane", Molecular Pharmacology, 36:;518-524 (1989).
Davies, et al. "Novel Entry to the Tropane System by Reaction of Rhodium (II) Acetate Stabilized Vinylcarbenoids with Pyrroles", Tetrahedron Letters, vol. 30, No. 35, pp. 4653-4656 (1989).
Davies et al., "Chemistry of Vinylcarbenoids with a Single Electron Withdrawing Group. An Approach to Tropane Alkaloids" American Chemical Society, Dec. 5-7, 1990, pp. 181-182.
Lewin, et al., "2-.beta.-Substituted Analogues of Cocaine. Synthesis and Inhibition of Binding to the Cocaine Receptor", Journal of Medicial Chemistry, vol. 35, No. 1 (1992) pp. 135-140.
Abraham et al., "N-Modified Analogues of Cocaine. Synthesis and Inhibition of Binding to the Cocaine Receptor", Journal of Medici Chemistry, vol. 35, No. 1 (1992) pp. 141-144.
Kozikowski et al., "Use of Nitrile Oxide Cycloaddition (NOC) Chemistry in the Synthesis of Cocaine Analogues; Mazindol Binding and Dopamine Reuptake Sutides", Medicinal Chemistry Research, vol. 1 (1991) pp. 312-321.
Childers Steven R.
Davies Huw M. L.
Saikali Elie
Rotman Alan L.
Wake Forest University
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