Biologically active substance, bestatin, and production thereof

Details Biologically active substance, bestatin, and production thereof Biologically active substance, bestatin, and production thereof

1976-05-27

1977-10-04

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424309, C07C10172

Patent

active

040524493

ABSTRACT:
This invention provides a new chemical named bestatin which inhibits aminopeptidase B, leucine aminopeptidase and bleomycin hydrolase, enhances the antitumor effect of bleomycin, has the chemical name [(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoyl]-L-leucine and has the following structure: ##STR1## and also provides a process for the production thereof which comprises cultivating a strain of streptomyces which produces bestatin in a nutrient medium under aerobic conditions until substantial activity inhibitory to aminopeptidase B is imparted to said cultured medium and then recovering said bestatin from said cultured medium. A preferred strain is Streptomyces olivoreticuli FERM-P No. 2590 (A.T.C.C. 31159).

REFERENCES:
J. Antibiotics 29, 97-101 (1976).
Antibiotics & Chemotherapy 7, (1957) 435-442.

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