Biologically active protein fragments containing specific bindin

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Albumin

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530350, 435 691, 4352523, 4353201, C07K 1476

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active

057805946

ABSTRACT:
In accordance with the present invention, biologically active protein fragments can be constructed which contain only those specific portions of the serum albumin family of proteins such as regions known as subdomains IIA and IIIA which are primarily responsible for the binding properties of the serum albumins. The artificial serums that can be prepared from these biologically active protein fragments are advantageous in that they can be produced much more easily than serums containing the whole albumin, yet still retain all or most of the original binding potential of the full albumin proteins. In addition, since the protein fragment serums of the present invention can be made from non-natural sources using conventional recombinant DNA techniques, they are far safer than serums containing natural albumin because they do not carry the potentially harmful viruses and other contaminants that will be found in the natural substances.

REFERENCES:
He et al "Atomic Structure and Chemistry . . . " Nature 358 pp. 209-215, Jul. 16, 1992.
Carter et al "Three Dimensional Structure . . . " Science 244 pp. 1195-1198, Jun. 9, 1989.
Hirayama et al. "Rapid Confirmation and Revision . . . " Biochem Biophys. Res. Comm. vol. 173, No. 2 pp. 639-646 Dec. 14, 1990.
Hamilton et al. (1991) Locations of the Three Primary Binding Sites for Long-Chain Fatty Acids on Bovine Serum Albumin. Proc. Natl. Acad. Sci. USA, vol.88, pp. 2051-2054.
Johanson et al. (1981) Refolding of Bovine Serum Albumin and Its Proteolytic Fragments. J. Biol. Chem. vol. 256, No. 1, pp. 445-450.
Carter et al., "Structure of human serum albumin", Science, vol. 249, pp. 302-303, Jul. 20, 1990.
NASA, Tech Briefs, Mar. 1992, p. 94, Author: Daniel C. Carter, Sequences of Amino Acids for Human Serum Albumin.

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