Biologically active product produced by streptococcus pyogenes a

Details Biologically active product produced by streptococcus pyogenes a Biologically active product produced by streptococcus pyogenes a

1994-02-18

1996-09-24

Fleisher, Mindy

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

530416, 530417, 435 29, 4352534, 435803, 435885, C07K 14315, C07K 136, C12N 120, C12Q 102

Patent

active

055592112

ABSTRACT:
A biologically active, stable protein with a molecular weight of 20,000 to 30,000 and an isoelectric point of 8.0-10.0 is produced from the culture fluid of Streptococcus pyogenes and purified. The purified biologically active protein produces lymphocyte proliferation, provides protection against bacterial and viral infection and restricts minor metastasis.

REFERENCES:
patent: 4772584 (1988-09-01), Clearly et al.
patent: 4929547 (1990-05-01), Kanoaka et al.
Hoh et al. Infect Immun. 60(8) 3128-3135 1992.
Manjua et al. J. Immunol 124(1) 261-267 1980.
Joklik et al "Zinsser Microbiology" 20th ed. 8-17, 749-782 1992.
Harris et al. "Protein Purification Methods" p. 61-63, 148-160, 180-181, 295-301, 1991.
Hoh et al. "Mechanism of Stimulation of T Cells by Streptococcus pyogenes: Isolation of a Major Mitogenic Factor, Cytoplasmic Membrane Associated Protein" Infect Immun. 60(8) 3128-3135 1992.
Manjula et al. "Studies on Group A Streptococcal M-Proteins: Purification of Type 5-M-Protein & Comparison of its Amino Terminal Sequence w/ Two Immunologically Unrelated M Protein Molecules" J. Immunol. 124(1) 261-267 1980.

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