Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1995-05-22
1998-01-06
Allen, Marianne P.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
530350, 530399, 536 234, 435 697, 435325, C07K 1449, C12N 1518, A61K 3818
Patent
active
057054843
ABSTRACT:
The present invention provides a biologically active multimeric polypeptide molecule in which two or more monomeric subunits are linked together as a single polypeptide ("fusion multimer"). These fusion multimers are more easily and rapidly refolded than unfused multimers, because the reactions necessary to generate the biologically active multimeric form of the polypeptide proceed with first order, rather than second or higher order, reaction kinetics. Fusion multimers also eliminate the simultaneous formation of undesired polypeptide by-products during refolding. The fusion multimers of the present invention specifically include PDGF fusion dimers.
REFERENCES:
patent: 4766073 (1988-08-01), Murray et al.
Hoppe, J. et al., Eur. J. Biochem., 187 (1) : 207-214, 1990.
Andersson, M. et al., J. Biol. Chem., 267 (16) : 11260-11266, 1992.
J. Hoppe et al., Preparation of biologically active platelet-derived growth factor isoforms AA and AB, Eur. J. Biochem, 187 (1), 207-214 (1990).
Andersson et al., Assignment of Interchain Disulfide Bonds in Platelet-derived Growth Factor (PDGF) and Evidence for Agonist Activity of Monomeric PDGF, J. Biol. Chem., 267 (16), 11260-11265 (1990).
Qian, S.W. et al., Identification of the structural doman that distinguishes the actions of the type 1 and 2 isoforms of transforming growth factor .beta. on endothelial cells, Proc. Natl. Acad. Sci. USA, (89), (1992).
Brinkmann et al., Independent domain folding of Pseudomonas exotoxin and single-chain immunotixins: Influence of interdomain connections, Proc.Natl.Acad.Sci. USA, (89) (1992).
Geisow, M.J., Molecular couturiers and designer proteins, Tibtech, (11) (1993).
Allen Marianne P.
Amgen Inc.
Eggert Joan D.
Levy Ron K.
Odre Steven M.
LandOfFree
Biologically active polypeptide fusion dimers does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Biologically active polypeptide fusion dimers, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Biologically active polypeptide fusion dimers will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2329225