Biologically active polypeptide and use thereof

Details Biologically active polypeptide and use thereof Biologically active polypeptide and use thereof

1988-01-22

1991-04-16

Warren, Charles F.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

25 or more amino acid residues in defined sequence

530858, 435 701, 514 2, 514 21, A61K 3702, C12P 2102, A01N 3718

Patent

active

050083716

ABSTRACT:
A biologically active polypeptide, method of obtaining same and use thereof are disclosed. The polypeptide is obtained through steps of cultivating a cell line established from Sarcophaga peregrina embryo to produce the same in a culture medium, as product of the cell line, isolating and purifying the same. The polypeptide shows an anti-virus activity.

REFERENCES:
patent: 4355104 (1982-10-01), Hultmark et al.
Okada et al., "Purification and Characterization of an Antibacterial Protein from Haemolymph of Sarcophraga peregrina (Flesh-Fly) Larvae", Biochem. J., vol. 211, pp. 727-734, 1983.
Okada et al., "Primary Structure of Sarcotoxin I, an Antibacterial Protein Induced in the Hemolymph of Sarcophaga peregrina (Flesh Fly) Larvae", J. Biol. Chem., vol. 260, pp. 7174-7177, 1985.
Lehrer et al., "Direct Inactivation of Viruses by MCP-1 and MCP-2, Natural Peptide Antibiotics from Rabbit Leukocytes", J. of Virology, vol. 54, 467-472, 1985.
Komano et al., "Purification of Sarcophage (Flesh Fly) Lectin and Detection of Sarcotoxins in the Culture Medium of NIH-Sape-4, an Embryonic Cell Line of Sarcophaga peregnina", Biochem. J. (1987), 248, 217-222.
"Eur. J. Biochem", vol. 106, p. 7 (1980).

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