Biologically active peptides which inhibit toxoplasma multiplica

Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 6 to 7 amino acid residues in defined sequence

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530330, C07K 706

Patent

active

048974633

ABSTRACT:
Biologically active peptides each having an activity to inhibit multiplication of toxoplasma and having a structure composed of amino acid sequence by the formula Gly-Glu-Glu-Glu-Glu-Glu; Glu-Glu-Glu-Glu-Glu; Asp-Asp-Asp-Asp-Asp; or Ala-Asp-Asp-Asp-Asp-Asp. These peptides are estimated to form active units or cores of Obioactin. The peptides may be applied in various dosage forms to human being and animals as immunoregulators against attack by toxoplasma, since they exhibit no specie specificity and have Toxo-GIF activities of 10 or more times on weight basis, and 40 or more time on molar basis, of that of the crude Obioactin.

REFERENCES:
patent: 4482543 (1984-11-01), Suzuki et al.
patent: 4528189 (1985-07-01), Lederis et al.
CA, vol. 108(5), 1988, p. 33938-Characterization of Multiple Forms of Maize Seedling Protein Kinases Reminiscent of Animal Casein Kinases S(Type 1), TS(Type 2), Dobrowolska et al.

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