Biologically active peptides structurally related to regions wit

Details Biologically active peptides structurally related to regions wit Biologically active peptides structurally related to regions wit

1983-06-04

1987-10-13

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 16, 530329, A61K 3726, C07K 706

Patent

active

046998977

ABSTRACT:
Disclosed are novel synthetic peptides having primary structural homology to a continuous sequence of amino acid residues of human growth hormone in a region spanning positions thirty-two to forty-six ("hGH.sub.32-46 ", or "deletion peptide"). In preferred forms, peptides of the invention comprehend: duplicate portions (i.e., sequence fragments) of hGH.sub.32-46 ; stereochemical analogs and fragment analogs of hGH.sub.32-46 including one or more amino acid residues in D-isomeric configuration; and, "interspecies" analogs and fragment analogs of hGH.sub.32-46 including one or more non-homologous amino acid residues duplicating variant residues present in corresponding positions in corresponding regions of heterologous species growth hormones. Peptides of the invention are administered to mammals contemporaneously with exogenous insulin to generate hypoglycemic effects greater than available through administration of insulin alone. A presently preferred heptapeptide has the sequence, NH.sub.2 -Glu-Glu-Ala-Tyr-Ile-Pro-Lys-COOH, and has insulin-potentiating activity greater than hGH.sub.32-46.

REFERENCES:
patent: 2843525 (1958-07-01), Robinson et al.
patent: 3326763 (1967-06-01), Antoniades et al.
patent: 3698912 (1972-10-01), Winitz
patent: 3868358 (1975-02-01), Jackson
patent: 3912807 (1975-10-01), Alburn et al.
patent: 3941763 (1976-03-01), Sarantakis
patent: 4107158 (1978-08-01), LeFrancier
patent: 4125606 (1978-11-01), Bornstein
patent: 4150121 (1979-04-01), Dietze et al.
patent: 4558033 (1985-12-01), Rudman
IUPAC-1UB Commission on Biological Nomenclature, The Journal of Biological Chemistry, 247, No. 4, 977-983 (1972).
Yudave et al., Biokhimiya, 41(5), 843-846.
Rivier et al., 8th American Peptide Symposium, Tucson, Arizona, p. 237 (1983).
Chillemi, J. Chem. Soc., Perkin Trans 1(7), 1913-1917 (1981).
Morikawa et al., Mol. Cell. Biol., 4(2) 228-231 (1984).
Vanderlaan et al., J. Protein Chem., 2(4), 341-346 (1983).
Bornstein, review at pp. 41-44 in Growth Hormones and Related Peptides (A. Pecile, et al., eds.), Excerpta Medica, Amsterdam-Oxford (1976).
Frigeri, et al., Biochem. Biophys. Res. Comm., 91: 778-782 (1979).
Frigeri, et al., Proc. 64th Ann. Meeting of the Endocrine Society, San Francisco (Abstract 88), p. 101, Jun. 1982.
Goodman, Metabolism, 19:849-855 (1970).
Goodman, Ann. N.Y. Acad. Sci., 148: 419-440 (1968).
Lewis, et al., J. Biol. Chem., 253: 2679-2685 (1975).
Lewis, et al., Biochem. Biophys. Res. Comm., 92: 511-516 (1980).
Lewis, et al., Endocrine Res. Comm., 8: 155-164 (1981).
Sawyer, et al., PNAS (U.S.A.), 77(10): 5754-5758 (1980).
Swislocki, et al., Endocrinology, 76: 665-672 (1965).
Yudaev, et al., Biochem. Biophys. Res. Comm., 110: 866-872 (1983).
Atlas of Protein Sequence and Structure, vol. 5, Supp. 2, pp. 120-121 (M. Dayhoff, ed., National Biomedical Research Foundation, 1976).
Rudinger, pp. 1-7 in Peptide Hormones, Parsons (ed.), University Park Press, Baltimore (1976).

Affiliated with

Also associated with

Rating

Biologically active peptides structurally related to regions wit does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Biologically active peptides structurally related to regions wit, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Biologically active peptides structurally related to regions wit will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-411464