Biologically active peptides having n-terminal substitutions

Details Biologically active peptides having n-terminal substitutions Biologically active peptides having n-terminal substitutions

1995-06-05

1997-11-11

Tsang, Cecilia J.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

15 to 23 amino acid residues in defined sequence

530327, 514 13, 514 14, C07K 708, A61K 3811

Patent

active

056865635

ABSTRACT:
An N-terminal substituted peptide or protein having the formula: ##STR1## X is a biologically active amphiphilic ion channel-forming peptide or protein. T is a lipophilic moiety, and preferably, T is: ##STR2## wherein R is a hydrocarbon (alkyl or aromatic or alkylaromatic) having at least 2 and no more than 10 carbon atoms. T is preferably an octanoyl group. W is T or hydrogen. The N-terminal substituted peptides and proteins have improved biological activity against target cells, viruses, and virally-infected cells.

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