Biologically active peptides having N-terminal substitutions

Details Biologically active peptides having N-terminal substitutions Biologically active peptides having N-terminal substitutions

1995-03-14

1997-08-05

Tsang, Cecilia J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530324, A61K 3800, C07K 1400

Patent

active

056542747

ABSTRACT:
An N-terminal substituted peptide or protein having the formula: ##STR1## X is a biologically active amphiphilic ion channel-forming peptide or protein. T is a lipophilic moiety, and preferably, T is: ##STR2## wherein R is a hydrocarbon (alkyl or aromatic or alkylaromatic) having at least 2 and no more than 10 carbon atoms. T is preferably an octanoyl group. W is T or hydrogen. The N-terminal substituted peptides and proteins have improved biological activity against target cells, viruses, and vitally-infected cells.

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