Biologically active peptides from functional domains of bacteric

Details Biologically active peptides from functional domains of bacteric Biologically active peptides from functional domains of bacteric

1998-12-31

2000-11-28

Davenport, Avis M.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

25 or more amino acid residues in defined sequence

530300, 530325, 530326, 514 12, 514 13, 4341851, A61K 3800

Patent

active

061537306

ABSTRACT:
The present invention provides peptides having an amino acid sequence that is the amino acid sequence of a human bactericidal/permeability-increasing protein (BPI) functional domain or a subsequence thereof, and variants of the sequence or subsequence thereof, having at least one of the BPI biological activities, such as heparin binding, heparin neutralization, LPS binding, LPS neutralization or bactericidal activity. The invention provides peptides and pharmaceutical compositions of such peptides for a variety of therapeutic uses.

REFERENCES:
patent: 5733872 (1998-03-01), Little
patent: 5856438 (1999-01-01), Little, II

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