Biologically active peptides from functional domains of bacteric

Details Biologically active peptides from functional domains of bacteric Biologically active peptides from functional domains of bacteric

1994-09-15

1997-07-29

Schain, Howard E.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

25 or more amino acid residues in defined sequence

530325, 530326, 530327, 530328, 530300, A61K 3800, C07K 500, C07K 700, C07K 1600

Patent

active

056523327

ABSTRACT:
The present invention provides peptides having an amino acid sequence that is the amino acid sequence of a human bactericidal/permeability-increasing protein (BPI) functional domain or a subsequence thereof, and variants of the sequence or subsequence thereof, having at least one of the BPI biological activities, such as heparin binding, heparin neutralization, LPS binding, LPS neutralization or bactericidal activity. The invention provides peptides and pharmaceutical compositions of such peptides for a variety of therapeutic uses.

REFERENCES:
patent: 5088164 (1992-02-01), Maione et al.
patent: 5112946 (1992-05-01), Maione
patent: 5348942 (1994-09-01), Little, II et al.
Little et al., J. of Biol. Chem., vol. 269, No. 3, Jan. 21, 1994, pp. 1865-1872.
Ool et al., J. of Biol Chem., vol. 262, No. 31, Nov. 5, 1987, pp. 14891-14894.
Gray et al., J. of Biol Chem., vol. 264, No. 16, Jun. 5, 1989, pp. 9505-9509.
Boman et al., 1993, "Mechanisms of Action on Escherichia coli of Cecropin P1 and PR-39, Two Antibacterial Peptides from Pig Intestine", Infect. Immunol., 61: 2978-2984.
Charles et al., 1989, "The Three-Dimensional Structure of Bovine Platelet factor 4 at 3.0.ANG. Resolution", J. Biol. Chem. 264: 29092-29099.
Cook et al., 1992, "Platelet Factor 4 Efficiently Reverses Heparin Anticoagulation in the rat without Adverse Effects of Heparin-protamine Complexes", Circulation 85: 1102-1109.
Elsbach et al., 1992, "Oxygen-Independent Antimicrobial Systems of Phagocytes", Inflammation: Basic Principles and Correlates, 2d ed., Review Press, Ltd., Chapter 30, pp. 603-636.
Elsbach et al., 1979, "Separation and Purification of a Potent Bactericidal/Permeability-increasing Protein and a Closely Associated Phospholipase A.sub.2 from rabbit Polymorphonuclear Leukocytes", J. Biol. Chem. 254: 11000-11009.
Folkman et al., 1992, "Abiogenesis and Inflammation", Inflammation: Basic Principles and Correlates, 2d ed., Review Press, Ltd., Chapter 40, pp. 821-829.
Gammon et al., 1991, "T Cell Determinant Structure: Cores and Determinant Envelopes in Three Major Histocompatability Complex Haplotypes", J. Exp. Med. 173: 609-617.
Garcia et al., 1983, "Repligen IND for Platelet Factor", BioWorld Today, p. 5, Jan. 11, 1983.
Gazzano-Santoro et al., 1992, "High Affinity Binding of the Bactericidal/Permeability-increasing Protein and a Recombinant Amino-terminal Fragment of the Lipid-A Region of Lipopolysaccharide", Infect. Immunol. 60 4754-4761.
Gray et al., 1989, "Clonming of the cDNA of a Human Neutrophil Bactericidal Protein", J. Biol. Chem. 264: 9505-9509.
Guo et al., 1992, "Heparin-binding Peptides from the Type I Repeats of Thrombospondin", J. Biol. Chem. 267: 19349-19355.
Heyderman et al., 1992, "Reduction of the Anticoagulant Activity of Glycosaminoglycans on the Surface of the Vascular Endfothelium by Endotoxin and Neutrophils: Evaluation of an Amidolytic Assay", Thrombosis Res. 67:pp. 677-685.
Hiti-Harper et al., "Platelet Factor 4: An Inhibitor of Collagenase", Science 199: 991-992.
Maeji et al., 1990, "Multi-pin Peptide Strategy for T Cell Determinant Analysis", J. Immunolog. Methods 134: 23-33.
Maione et al., 1991, "Inhibition of Tumor Growth in Mice by an Analogue of Platelet Factor 4 that Lacks Affinity for Heparin and Retains Potent Angiostatic Activity", Cancer Res. 51: 2077-2083.
Maione et al., 1992, CAS BioTech Updates 117: 226303.
Marra et al., 1992, "The Role of Bactericidal/Permeability-increasing Protein as a natural Inhibitor of Bacterial Endotoxin", J. Immunol. 148: 532-537.
Merrifield et al., 1966, "Instrument for Automated Synthesis of Peptides", Anal. Chem. 38: 1905-1914.
Merrifield et al., 1963, "Solid Phase Peptide Synthesis", J. Amer. Chem. Soc. 85: 2149-2154.
Miles et al., 1991, "Recombinant Platelet Factor 4 (rPF4) and a Non-heparin Binding Derivative Inhibits AIDS-Kaposi's Sarcoma Derived Cell Lines", VII International Conference on AIDS, 41: 108.
Ooi et al., 1991, "Endotoxion-neutralizing Properties of the 25kD N-terminal Fragment and a Newly-isolated 30kD C-terminal Fragment of the 55-60kD Bactericidal/Permeability-increasing Protein of Human Neutrophils", J. Exp. Med. 174: 649.
Peacock et al., 1992, "Angiobiogenesis Inhibition Suppresses Collagen Arthritis", J. Exp. Med. 175: 1135-1138.
Posnet & Tam, 1989, Methods in Enzymology 178: 739-746.
Repligen Corporation, 1992, Research in Review.
Stuart et al., "Nature and the Specificity of the Immune Response to Collagen in Tyoe II Collagen-induced Arthritis in Mice", J. Clin. Invest. 69: 673-683.
Takayama et al., 1987, "Absence of Lipopolysaccharide in the Lyme Disease Spirochete", Infect. and Immun. 55: 2311-2312.
Taylor et al., 1982, "Protamine is an Inhibitor of Angiogenesis", Nature 297: 307-312.
Tontsch et al., 1981, "Isolation, Characterization and Long-term Cultivation of Porcine and Murine Cerebral Capillary Endothelial Cells", Microvascular Res. 37: 148-161.
Wade et al., 1990, "All-D amino acid-containing chennel-forming antibotic peptides", Proc. Natl. Acad. Sci. USA 87: 4761-4765.
Weiss et al., 1987, "Cellular and Subcellular Localization of the Bactericidal/Permeability-increasing Protein of Neutrophils", Blood 69: 652-659.
Weiss et al., 1987, "Parrtial Characterization and Purification of Rabbit Granulocyte Factor that Increases Permeability of Escherichia coli", J. Clin. Invest. 55: 33-42.
Yayon et al., 1991, "Cell-surface, Heparin-like Molecules are required for Binding of Basic Fibroblast Growth to its Highy Affinity Receptor", Cell 64: 641-648.
Yong et al., 1988, "An Experimental Mouse Model of Yersinia-induced Reactive Arthritis", Microbial Pathogenesis 4: 305-310.
Zasloff et al., 1988, "Antimicrobial activity of synthetic magainin peptides and several analogues", Proc. Natl. Acad. Sci. USA 85: 910-913.

Affiliated with

Also associated with

Rating

Biologically active peptides from functional domains of bacteric does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Biologically active peptides from functional domains of bacteric, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Biologically active peptides from functional domains of bacteric will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-634643