Biologically active peptides from funcional domains of bacterici

Details Biologically active peptides from funcional domains of bacterici Biologically active peptides from funcional domains of bacterici

1995-06-07

1998-06-09

Carlson, Karen C.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

530324, 530325, 530326, C07K 700, C07K 708, C07K 704

Patent

active

057635676

ABSTRACT:
The present invention provides peptides having an amino acid sequence that is the amino acid sequence of a human bactericidal/permeability-increasing protein (BPI) functional domain or a subsequence thereof, and variants of the sequence or subsequence thereof, having at least one of the BPI biological activities, such as heparin binding, heparin neutralization, LPS binding, LPS neutralization or bactericidal activity. The invention provides peptides and pharmaceutical compositions of such peptides for a variety of therapeutic uses.

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