Biologically active peptide derived from frog (frog CNP)

Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 15 to 23 amino acid residues in defined sequence

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C07K 700, A61K 3702

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active

053367596

ABSTRACT:
A novel peptide that exhibits a natriuretic action and a vasodepressor activity, and hence, that is applicable for a diagnostic reagent. The novel peptide is manufactured by tile procedure of genetic engineering as well as by the methods of purification from frog brains or by chemical synthesis.

REFERENCES:
patent: 4904763 (1990-02-01), Matsuo et al.
patent: 5114923 (1992-05-01), Seilhamer et al.
Yoshihara et al. Biochem. Biophys. Res. Commun. (1990) 173(2) 591-8.
Minamino et al. Pept. Chem. (1991) 28 367-72.
Yoshihara et al, "Chemical Abstracts", Columbus, Apr. 1, 1991, vol. 114, No. 13; Minamino et al, Chemical Abstracts, Columbus, Aug. 19, 1991, vol. 115 No. 7; Nakao et al, Chemical Abstracts, Columbus, Nov. 19, 1990, vol. 113 No. 21.
Minamino et al; C-Type Natriuretic Peptide (CNP); Biochemical and Biophysical Research Communications; vol. 168, No. 2, 1990.
Minamino et al.; N-Terminally Extended Form of C-Type Natriuretic Peptide (DNP-53) Identified in Porcine Brain; vol. 170, No. 2, 1990.

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