Biologically active peptide derived from chicken (chicken CNP)

Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 15 to 23 amino acid residues in defined sequence

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C07K 700, A61K 3702

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active

053388305

ABSTRACT:
A novel peptide that exhibits a natriuretic action and a vasodepressor activity, and hence, that is applicable as a diagnostic reagent. The novel peptide is manufactured by the procedure of genetic engineering as well as by the methods of purification from chicken brains or by chemical synthesis.

REFERENCES:
patent: 4904763 (1990-02-01), Matsuo et al.
patent: 5114923 (1992-05-01), Seilhamer et al.
Arimura et al. Biochem. Biophys. Res. Commun. (1991) 174(1) 142-8.
Minamino et al. Pept. Chem. (1991) 28 367-72.
Nakao et al, Chemical Abstracts, Columbus, vol. 113, No. 21, Nov. 19, 1990.
Arimura et al., Chemical Abstracts, Columbus, vol. 114, No. 13, Apr. 1, 1991.
Minamino et al, Chemical Abstracts, Columbus, vol. 115, No. 7, Aug. 19, 1991.
Minamino et al; C-Type Natriuretic Peptide (CNP); Biochemical and Biophysical Research Communications; vol. 168, No. 2, 1990.
Minamino et al.; N-Terminally Extended Form of C-Type Natriuretic Peptide (DNP-53) Identified in Porcine Brain; vol. 170, No. 2, 1990.

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