Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Lymphokines – e.g. – interferons – interlukins – etc.
Patent
1986-12-15
1989-12-26
Moskowitz, Margaret
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Lymphokines, e.g., interferons, interlukins, etc.
530350, 530380, 530399, 4351723, 435 694, 514 2, 514 8, 514 21, C07K 1300, C07K 1514, A61K 3702
Patent
active
048899194
ABSTRACT:
Dimeric proteins having substantially the same biological activity as PDGF are disclosed. More specifically, the protein may have two substantially identical polypeptide chains, each of the chains being substantially homologous to the A-chain of PDGF. Alternatively, the protein may have two polypeptide chains that are substantially identical to the A-chain of PDGF. In addition, proteins comprising polypeptides that are variants or derivatives of the A-chain of PDGF are also disclosed. Therapeutic compositions containing these proteins and methods for enhancing the wound-healing process in warm-blooded animals are also disclosed.
REFERENCES:
patent: 4350687 (1982-09-01), Lipton et al.
patent: 4443546 (1984-04-01), Stemerman et al.
patent: 4479896 (1984-10-01), Antoniades
patent: 4568640 (1986-02-01), Rubin
patent: 4588585 (1986-05-01), Mark et al.
patent: 4590003 (1986-05-01), Twardzik et al.
patent: 4673640 (1987-06-01), Backman
Antoniades, P.N.A.S. U.S.A., 78(12): 7314-17, 1981.
Johnson et al., Biochem. Biophys. Res. Comm., 104(1), 66-74, 1982.
Deuel et al., J. Biol. Chem., 256(17), 8896-99, 1981.
Raines et al., J. Biol. Chem., 257(9), 5154-60, 1982.
Waterfield et al., Nature, 304(7), 35-39, 1983, (Jul.).
Kelly James D.
Murray Mark J.
Kushan Jeff P.
Moskowitz Margaret
ZymoGenetics Inc.
LandOfFree
Biologically active PDGF derived A-chain homodimers does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Biologically active PDGF derived A-chain homodimers, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Biologically active PDGF derived A-chain homodimers will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1577844