Biologically active PDGF A-chain homodimers

Details Biologically active PDGF A-chain homodimers Biologically active PDGF A-chain homodimers

1995-03-29

1999-12-21

Walsh, Stephen

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530324, 530399, A61K 3818, C07K 1449

Patent

active

060049294

ABSTRACT:
Dimeric proteins having substantially the same biological activity as PDGF are disclosed. More specifically, the protein may have two substantially identical polypeptide chains, each of the chains being substantially homologous to the A-chain of PDGF. Alternatively, the protein may have two polypeptide chains that are substantially identical to the A-chain of PDGF. In addition, proteins comprising polypeptides that are variants or derivatives of the A-chain of PDGF are also disclosed. Therapeutic compositions containing these proteins and methods for enhancing the wound-healing process in warm-blooded animals are also disclosed.

REFERENCES:
patent: 4889919 (1989-12-01), Murray et al.
Betsholtz et al. (Apr. 24, 1986) Nature 320, 695-699.
Heldin et al. (1980) J. Cell. Phys. 105, 235-246.
Deuel et al. (1984) J. Clin. Invest. 74, 669-676.
Heldin et al. (Feb. 6, 1986) Nature 319, 511-514.
Betsholtz et al., Biochemical and Biophysical Research Communications 117: 176-182, 1983.
Betsholtz et al., Cell 39: 447-457, 1984.

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